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학습 자료 둘러보기 →The highest priority intervention is to immediately discontinue the offending antipsychotic. This directly halts the central dopamine receptor blockade driving the crisis and is the cornerstone of treatment.
NMS is a life-threatening emergency marked by hyperthermia, generalized muscle rigidity, autonomic instability, and altered mental status. Muscle rigidity generates excessive heat, rapidly progressing to rhabdomyolysis with CPK levels often exceeding 20,000 U/L.
Supportive measures like cooling blankets or antipyretics are secondary and ineffective if the causative drug is not withdrawn first. Continuous monitoring is essential but does not replace the immediate removal of the trigger.
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