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학습 자료 둘러보기 →The immediate priority is to discontinue the offending agent (e.g., haloperidol) to halt the dopamine blockade driving the crisis. Simultaneously, initiate aggressive external cooling (e.g., cooling blankets, ice packs) to combat severe hyperthermia, which can rapidly lead to rhabdomyolysis and multi-organ failure.
Supportive care includes monitoring for complications. Antipyretics like acetaminophen are ineffective because the elevated temperature is centrally mediated, not a pyrogen-driven fever. Focus instead on managing autonomic instability and maintaining hydration to protect renal function from myoglobinuria.
Do not confuse NMS hyperthermia with infection-related fever. Delaying drug discontinuation or relying on antipyretics can be fatal. Monitor for cardiac arrhythmias due to severe autonomic dysfunction and electrolyte shifts.
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