Which combination of findings is MOST characteristic of amyotrophic lateral sclerosis?

• 1 Muscle atrophy and fasciculations together with hyperreflexia and spasticity ✓ 정답
• 2 Symmetric sensory loss in a stocking distribution with normal muscle strength
• 3 Isolated cerebellar ataxia with preserved muscle bulk and reflexes
• 4 Fluctuating weakness that improves markedly after a period of rest

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