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학습 자료 둘러보기 →Suspect differentiation syndrome in any patient with acute leukemia who develops acute dyspnea, fever, and hypotension. The pathophysiology involves a systemic inflammatory response with capillary leak, leading to non-cardiogenic pulmonary edema and respiratory failure.
The immediate nursing priority is to support oxygenation and ventilation. Administer high-flow oxygen to target SpO2 above 92% and prepare for emergency intubation. Simultaneously, notify the provider and prepare to administer dexamethasone as prescribed.
Do not delay respiratory support for diagnostic tests like ECG or labs. Avoid anxiolytics and sedatives that can depress respiratory drive before the airway is secured. Continuous monitoring for fluid overload and pericardial effusion is critical.
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