Oncological Emergencies

A nurse is assessing a 45-year-old patient with acute lymphoblastic leukemia who was admitted 2 hours ago with complaints of severe headache, confusion, and blurred vision. Which assessment finding would be most indicative of tumor lysis syndrome?

1 Serum calcium level of 12.5 mg/dL (3.1 mmol/L)
2 Serum potassium level of 6.8 mEq/L (6.8 mmol/L) ✓ 정답
3 Serum sodium level of 128 mEq/L (128 mmol/L)
4 Serum magnesium level of 1.2 mg/dL (0.5 mmol/L)

해설

Hyperkalemia (elevated potassium) is most indicative of tumor lysis syndrome due to rapid cell destruction. Other electrolyte imbalances may occur but are less specific to TLS.

같은 주제 다음 문제A nurse is caring for a patient with acute lymphoblastic leukemia who suddenly develops se…이 문제가 수록된 문제집[개념+기출] 엔클렉스(NCLEX), 이거 하나면 됩니다69,000원

Understanding the Clinical Scenario

This patient with acute lymphoblastic leukemia (ALL) is presenting with neurological symptoms — severe headache, confusion, and blurred vision — just 2 hours after admission. While these symptoms themselves might point to an intracranial event (as highlighted in the case report by Lai et al., where intracranial hemorrhage co-occurred with spontaneous tumor lysis syndrome), the question asks you to identify the laboratory derangement most indicative of tumor lysis syndrome (TLS). TLS is an oncologic emergency driven by the rapid destruction of malignant cells, which release massive amounts of intracellular contents into the bloodstream. The hallmark metabolic triad involves hyperkalemia, hyperphosphatemia, and hypocalcemia (secondary to calcium-phosphate precipitation), often accompanied by hyperuricemia.

Why Hyperkalemia is the Most Indicative Finding

Among the options provided, a serum potassium of 6.8 mEq/L is the most classic and immediately life-threatening laboratory abnormality in TLS. Leukemic cells have a high intracellular potassium concentration. When these cells lyse rapidly — whether spontaneously as in the cases described by Asfaw et al. and Soliman et al., or following chemotherapy — potassium floods the extracellular space. The resulting hyperkalemia is the primary cause of fatal arrhythmias in TLS. Soliman et al. specifically emphasize that prompt recognition and treatment of hyperkalemia-induced arrhythmias in TLS is vital, as these can be life-threatening and may lead to renal failure, arrhythmias, or multi-organ failure if untreated.

The other options are less specific or even contradictory to the typical TLS picture:
- Hypercalcemia (12.5 mg/dL) is not characteristic of TLS; in fact, TLS causes hypocalcemia because phosphate released from cells binds to calcium and forms insoluble calcium-phosphate complexes.
- Hyponatremia (128 mEq/L) is a nonspecific finding that can occur in many oncologic conditions (e.g., SIADH) but is not a defining metabolic feature of TLS.
- Hypomagnesemia (1.2 mg/dL) can be seen in various clinical contexts but lacks the specificity and immediate danger of severe hyperkalemia in the setting of suspected TLS.

Connecting to the Patient's Presentation

This patient’s neurological symptoms — severe headache, confusion, and blurred vision — are not directly caused by hyperkalemia. However, the case by Lai et al. provides a crucial clinical pearl: spontaneous TLS and catastrophic intracranial hemorrhage can present simultaneously in aggressive leukemias such as KMT2A-rearranged ALL. The neurological decline may stem from intracranial bleeding or leukostasis, while the concurrent metabolic crisis of TLS unfolds silently on the laboratory panel. As the nurse, recognizing that a profoundly elevated potassium level in a patient with a high-burden hematologic malignancy signals TLS allows you to anticipate the need for continuous cardiac monitoring, urgent nephrology consultation, and rapid initiation of therapies like calcium gluconate (to stabilize the myocardium), insulin with glucose, and potentially dialysis — interventions that directly prevent death from hyperkalemic arrhythmias, as reinforced by the simulation-based training outlined by Soliman et al.

NCLEX Question Bank 엔클렉스 3,445 문제 · 로그인 없이 바로 볼 수 있어요

마이메르시로 국가고시 완벽 대비

기출문제와 상세 해설을 무료로. 내 약점을 분석하고 진도를 관리하며 더 똑똑하게 공부하세요.

무료로 시작하기

App Store Google Play

학습 참고용입니다. 실제 임상은 최신 지침과 소속 기관 프로토콜을 따르세요.

이 문제가 수록된 문제집 [개념+기출] 엔클렉스(NCLEX), 이거 하나면 됩니다 문제집 3,445문제 · 69,000원

문제집 보기 다음 문제

같은 단원 문제

마이메르시로 국가고시 완벽 대비

기출문제와 상세 해설을 무료로. 내 약점을 분석하고 진도를 관리하며 더 똑똑하게 공부하세요.

무료로 시작하기

다음 문제 무료로 시작하기

성장을 멈추지 마세요

A nurse is assessing a 45-year-old patient with acute lymphoblastic leukemia who was admitted 2 hours ago with complaints of severe headache, confusion, and blurred vision. Which assessment finding would be most indicative of tumor lysis syndrome?

마이메르시로 국가고시 완벽 대비