Oncological Emergencies

A nurse is caring for a patient with acute lymphoblastic leukemia who develops tumor lysis syndrome. The patient's laboratory results show: potassium 6.8 mEq/L, phosphorus 8.2 mg/dL, calcium 7.1 mg/dL, and uric acid 12.5 mg/dL. Which nursing intervention should be the priority?

1 Administer calcium gluconate 1 gram IV push immediately
2 Prepare for emergency hemodialysis consultation
3 Initiate continuous cardiac monitoring and obtain a 12-lead ECG ✓ 정답
4 Increase IV fluid rate to 200 mL/hour with normal saline

해설

Continuous cardiac monitoring is priority for severe hyperkalemia (K+ 6.8 mEq/L) to detect life-threatening arrhythmias. Other interventions are important but secondary to immediate cardiac surveillance.

같은 주제 다음 문제A nurse is assessing a 45-year-old patient with acute lymphoblastic leukemia who was admit…이 문제가 수록된 문제집[개념+기출] 엔클렉스(NCLEX), 이거 하나면 됩니다69,000원

Understanding the Pathophysiology
The laboratory values presented are a classic picture of tumor lysis syndrome (TLS), an oncologic emergency. The rapid destruction of leukemia cells releases massive amounts of intracellular contents into the bloodstream, overwhelming the body's homeostatic mechanisms. Specifically, the potassium of 6.8 mEq/L represents severe hyperkalemia, which is the most immediately life-threatening abnormality here. While the hyperphosphatemia (8.2 mg/dL), secondary hypocalcemia (7.1 mg/dL), and hyperuricemia (12.5 mg/dL) all require management, they do not pose the same immediate, second-to-second threat to life as a potassium level above 6.5 mEq/L. The primary danger of severe hyperkalemia is its destabilizing effect on the cardiac resting membrane potential, which can precipitate a fatal tachyarrhythmia or cardiac arrest without warning ^[1].

Why Continuous Cardiac Monitoring and an ECG are the Priority
The clinical priority is to assess the electrical impact of the hyperkalemia on the myocardium. The simulation-based evidence emphasizes that prompt recognition and treatment of hyperkalemia-induced arrhythmias in the context of TLS is vital, as these arrhythmias are life-threatening ^[1]. Before administering any treatment, the nurse must first determine if the patient is already exhibiting cardiotoxic effects. A serum potassium level of 6.8 mEq/L is a critical value that places the patient at high risk for developing peaked T-waves, loss of P-waves, a widened QRS complex, and eventually a sine-wave pattern leading to ventricular fibrillation or asystole. Initiating continuous cardiac monitoring and obtaining a 12-lead ECG provides an immediate, real-time assessment of the cardiac rhythm and the presence of any conduction delays. This diagnostic step is essential to guide the urgency and sequence of subsequent interventions and is a standard, non-invasive, and rapid nursing action that can be performed at the bedside immediately.

Analysis of Other Options
- Administer calcium gluconate 1 gram IV push immediately: Calcium gluconate is a critical treatment for stabilizing the cardiac membrane in hyperkalemia, but it does not lower the serum potassium level. While it would be indicated if the ECG shows significant changes (e.g., loss of P-waves, wide QRS), administering it blindly without first checking the ECG bypasses a crucial assessment step. The priority is to evaluate the patient's cardiac status first to determine the need for and timing of this medication ^[1].
- Prepare for emergency hemodialysis consultation: Hemodialysis is the most definitive method for removing potassium, phosphorus, and uric acid from the blood and would be indicated for this patient with severe TLS and renal dysfunction. However, arranging dialysis is a secondary intervention. The immediate, life-saving priority is to assess for and manage the cardiotoxic effects of the existing hyperkalemia, as a fatal arrhythmia can occur in the time it takes to set up dialysis.
- Increase IV fluid rate to 200 mL/hour with normal saline: Aggressive IV fluid administration is a cornerstone of TLS prevention and management, as it helps dilute serum solutes and promote renal excretion of potassium and uric acid. However, this is a preventive and ongoing management strategy, not the priority action for a patient with a potassium level of 6.8 mEq/L who is at immediate risk for a lethal cardiac event. The cardiac rhythm must be assessed and secured first.

References (research sources)

[1]
Recognition and Management of Hyperkalemia-Induced Tachyarrhythmia in Pediatric Spontaneous Tumor Lysis Syndrome: A Simulation Case.Research articleSoliman YH, Kochhar M, Petrone G, Wing R, Sojar SH. (2026) · DOI: 10.7759/cureus.107494

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A nurse is caring for a patient with acute lymphoblastic leukemia who develops tumor lysis syndrome. The patient's laboratory results show: potassium 6.8 mEq/L, phosphorus 8.2 mg/dL, calcium 7.1 mg/dL, and uric acid 12.5 mg/dL. Which nursing intervention should be the priority?

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