Several days after starting an oxidant drug, a patient develops anemia. The smear shows bite cells, and a supravital stain reveals Heinz bodies. Which deficiency is most likely?
1Glucose-6-phosphate dehydrogenase deficiency✓ 정답
2Pyruvate kinase deficiency of the glycolytic pathway
3Hereditary elliptocytosis of the red cell membrane
4Paroxysmal nocturnal hemoglobinuria with hemolysis
해설
Oxidative damage denatures hemoglobin into Heinz bodies, and the spleen removes those inclusions, producing bite cells. The characteristic features are an oxidative trigger such as a drug or infection and an episodic presentation.