Marked granulocytic leukocytosis with basophilia is present, and chronic myeloid leukemia is suspected. Which …

Question

Marked granulocytic leukocytosis with basophilia is present, and chronic myeloid leukemia is suspected. Which finding most specifically supports the diagnosis?

Accepted Answer

보기 2: BCR::ABL1 fusion from t(9;22)

CML is defined by the BCR::ABL1 fusion, usually created by the Philadelphia chromosome translocation t(9;22).

Answer

보기 1: JAK2 V617F without other findings

Answer

보기 3: Isolated factor V Leiden

Answer

보기 4: Loss of all immunoglobulin genes

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Marked granulocytic leukocytosis with basophilia is present, and chronic myeloid leukemia is suspected. Which finding most specifically supports the diagnosis?

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