A patient with recurrent thrombosis has a prolonged aPTT that does not correct in a mixing study. A phospholip…

Question

A patient with recurrent thrombosis has a prolonged aPTT that does not correct in a mixing study. A phospholipid-dependent confirmatory test shortens the clotting time. What is the best interpretation?

Accepted Answer

보기 3: A lupus anticoagulant is likely

Failure to correct suggests an inhibitor, and phospholipid dependence supports lupus anticoagulant. Despite prolonging phospholipid-dependent clotting tests in vitro, it is associated clinically with thrombosis.

Answer

보기 1: Factor VIII deficiency

Answer

보기 2: Fibrinogen deficiency

Answer

보기 4: The specimen proves vitamin K excess

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A patient with recurrent thrombosis has a prolonged aPTT that does not correct in a mixing study. A phospholipid-dependent confirmatory test shortens the clotting time. What is the best interpretation?

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