A patient with recurrent thrombosis has a prolonged aPTT that does not correct in a mixing study. A phospholipid-dependent confirmatory test shortens the clotting time. What is the best interpretation?
1Factor VIII deficiency
2Fibrinogen deficiency
3A lupus anticoagulant is likely✓ 정답
4The specimen proves vitamin K excess
해설
Failure to correct suggests an inhibitor, and phospholipid dependence supports lupus anticoagulant. Despite prolonging phospholipid-dependent clotting tests in vitro, it is associated clinically with thrombosis.