A patient has chronic hemolysis, spherocytes, an increased MCHC, and a negative DAT. Which specialized screening result supports hereditary spherocytosis?
1Increased fluorescence in the EMA-binding test
2Absent reticulocytes in every case
3Positive sickle solubility only
4Decreased eosin-5-maleimide fluorescence✓ 정답
해설
Reduced binding of eosin-5-maleimide to affected red-cell membrane proteins produces decreased fluorescence and supports hereditary spherocytosis.