A patient presents one hour after a single acute acetaminoph… | 마이메르시 MyMerci
이 문제가 수록된 문제집미국 임상병리사 MLS(ASCP/ASCPi) 문제은행·CAT문제집 보기
Chemistry · 임상화학
문제
A patient presents one hour after a single acute acetaminophen ingestion. Why is a level obtained at four hours after ingestion more appropriate for nomogram interpretation?
1Acetaminophen absorption is delayed and only begins at four hours post-ingestion, due to slow gastric emptying and first-pass metabolism
2The nomogram requires urine concentrations, which peak at four hours after ingestion, making earlier samples unreliable for risk assessment
3Earlier concentrations may precede complete absorption and are not interpreted on the treatment nomogram✓ 정답
4Serum concentrations fall to undetectable levels exactly four hours after ingestion, as the drug is rapidly metabolized and excreted
해설
The acute-ingestion treatment nomogram is applied to a serum concentration obtained at least four hours after a known single ingestion, when absorption is expected to be sufficiently complete.