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학습 자료 둘러보기 →Opioid analgesics bind to mu-opioid receptors in the gut, directly suppressing peristalsis and increasing fluid absorption. This effect does not diminish over time, unlike nausea or sedation.
A preventive bowel regimen should be initiated concurrently with opioid therapy. It typically combines a stool softener (e.g., docusate) and a stimulant laxative (e.g., senna) to counteract reduced motility.
Avoid bulk-forming laxatives (e.g., psyllium) without adequate fluid intake, as they can worsen obstruction in patients with slow transit. Monitor bowel movements at least every 48 hours.
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