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학습 자료 둘러보기 →In acute kidney injury, the failure to excrete metabolic waste leads to the accumulation of uremic toxins. These toxins directly depress the central nervous system, causing uremic encephalopathy.
The clinical spectrum ranges from subtle cognitive changes to seizures and coma. Progression to seizure activity is a life-threatening emergency that can compromise the airway. The prevalence of cognitive impairment in kidney disease is as high as 40%.
Do not encourage increased fluid intake in AKI; this can cause fluid overload and pulmonary edema. Avoid high-protein supplements during the oliguric phase, as protein metabolism increases uremic toxin production.
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