Reverse typing shows agglutination with both A1 and B cells in a patient with a markedly increased total prote…

Question

Reverse typing shows agglutination with both A1 and B cells in a patient with a markedly increased total protein. Microscopic examination shows stacked coin-like aggregates. What is the appropriate next step?

Accepted Answer

보기 2: Perform a saline replacement technique

Markedly increased total protein with agglutination in both reverse typing cells and a stacked-coin appearance on the smear indicates rouleaux. This is not true agglutination but red cells adhering because of excess protein, so it disperses with saline replacement. Prewarming addresses cold antibodies and autoadsorption addresses autoantibodies.

Answer

보기 1: Prewarm the sample to 37 degrees Celsius

Answer

보기 3: Perform an autoadsorption

Answer

보기 4: Repeat with a new lot of reagent cells

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Reverse typing shows agglutination with both A1 and B cells in a patient with a markedly increased total protein. Microscopic examination shows stacked coin-like aggregates. What is the appropriate next step?

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