Seven days after red cell transfusion, a patient develops jaundice, a falling hemoglobin, and a newly positive…

Question

Seven days after red cell transfusion, a patient develops jaundice, a falling hemoglobin, and a newly positive direct antiglobulin test. The antibody screen now detects anti-Jka. Which laboratory approach best supports investigation of a delayed hemolytic transfusion reaction?

Accepted Answer

보기 3: Test an eluate and posttransfusion plasma, and compare implicated antigen typing with pretransfusion or donor records

A delayed hemolytic transfusion reaction is investigated by comparing pre- and posttransfusion findings, identifying antibody in plasma or an eluate, and determining whether transfused cells carried the corresponding antigen.

Answer

보기 1: Repeat only the patient's forward ABO type and Rh phenotype on a new sample to rule out clerical error, ensuring accurate identification

Answer

보기 2: Perform a platelet count, fibrinogen assay, and D-dimer to assess for disseminated intravascular coagulation

Answer

보기 4: Issue additional crossmatch-incompatible red cells to reproduce the reaction and confirm specificity

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Seven days after red cell transfusion, a patient develops jaundice, a falling hemoglobin, and a newly positive direct antiglobulin test. The antibody screen now detects anti-Jka. Which laboratory approach best supports investigation of a delayed hemolytic transfusion reaction?

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