Five days after a red cell transfusion, a patient has an unexplained fall in hemoglobin, an increased bilirubi…

Question

Five days after a red cell transfusion, a patient has an unexplained fall in hemoglobin, an increased bilirubin, and a newly positive direct antiglobulin test with anti-IgG. What is the most likely diagnosis?

Accepted Answer

보기 4: Delayed hemolytic transfusion reaction

Timing is decisive. Hemolysis appearing several days after transfusion, rather than during or immediately after it, reflects a secondary immune response with an anamnestic rise in antibody. This is a delayed hemolytic transfusion reaction; an acute hemolytic reaction presents during or right after the transfusion.

Answer

보기 1: Acute hemolytic transfusion reaction

Answer

보기 2: Febrile nonhemolytic transfusion reaction

Answer

보기 3: Transfusion-associated circulatory overload

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Five days after a red cell transfusion, a patient has an unexplained fall in hemoglobin, an increased bilirubin, and a newly positive direct antiglobulin test with anti-IgG. What is the most likely diagnosis?

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