A previously transfused patient has a negative antibody screen, but one of three donor units is incompatible a…

Question

A previously transfused patient has a negative antibody screen, but one of three donor units is incompatible at the antiglobulin phase. What is the most likely cause?

Accepted Answer

보기 1: An antibody to a low-incidence antigen present on that donor unit

Screening cell panels usually lack low-incidence antigens, so an antibody to a low-incidence antigen is missed on screening and shows up only against the one donor unit that carries that antigen. A cold autoantibody or an ABO error would make several units incompatible, not just one.

Answer

보기 2: A cold reacting autoantibody that is active at the antiglobulin phase

Answer

보기 3: An ABO typing error involving the patient sample or that unit

Answer

보기 4: Rouleaux formation caused by an increased serum protein level

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A previously transfused patient has a negative antibody screen, but one of three donor units is incompatible at the antiglobulin phase. What is the most likely cause?

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