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학습 자료 둘러보기 →Apply the SPUR mnemonic: Severe infections, Persistent infections, Unusual organisms (opportunistic), and Recurrent infections with a family history. A history dating back to childhood is key.
Suspect a T-cell or combined defect when infections involve opportunistic pathogens like Pneumocystis jirovecii or invasive fungi. This differs from B-cell deficiencies, which present with recurrent sinopulmonary infections from encapsulated bacteria.
Do not attribute recurrent infections solely to secondary causes without a thorough history. A normal WBC count does not rule out PID; specific lymphocyte subsets and immunoglobulin levels must be evaluated.
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