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학습 자료 둘러보기 →In severe aplastic anemia with a WBC of 1,200/mm³, assume an ANC <500/µL. This profound neutropenia makes overwhelming sepsis the most immediate threat, often presenting only with fever as the host cannot mount a typical inflammatory response.
The first step is to implement strict protective isolation in a private room with positive-pressure airflow and HEPA filtration. All staff and visitors must perform meticulous hand hygiene and wear appropriate personal protective equipment to prevent introducing pathogens.
Avoid rectal temperatures, suppositories, and IM injections due to concurrent severe thrombocytopenia (platelets 5,000/mm³). Any invasive procedure creates a portal for both infection and uncontrolled bleeding.
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