In a severe exacerbation with PEFR ≤ 40% of personal best, the immediate priority is to reverse bronchoconstriction using a short-acting beta-2 agonist (SABA) like albuterol via nebulizer or MDI with spacer.
Position the child in an upright or semi-Fowler's position to optimize lung expansion. Lying flat can worsen dyspnea and should be avoided.
While oxygen therapy is given for hypoxia and systemic corticosteroids reduce inflammation, neither acts as rapidly as inhaled SABAs to relieve the immediate life-threatening bronchospasm. Do not delay bronchodilator administration.
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