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학습 자료 둘러보기 →In Shiga toxin-producing E. coli HUS, Shiga toxin binds to Gb3 receptors on CNS endothelium, causing thrombotic microangiopathy. This makes neurological involvement the most critical extrarenal threat.
Perform frequent neurological checks (level of consciousness, pupillary response, motor strength) at least every 1-2 hours. Monitor for subtle changes: irritability, confusion, visual disturbances, or seizure activity.
Do not administer antiplatelet agents like aspirin due to severe thrombocytopenia. Avoid aggressive fluid resuscitation in the setting of oliguria and hypertension to prevent pulmonary edema.
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