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학습 자료 둘러보기 →A positive antinuclear antibody (ANA) titer of 1:320 with a homogeneous pattern is a highly sensitive screening finding for systemic autoimmune conditions, most notably systemic lupus erythematosus (SLE). This titer is considered significantly elevated and reflects a loss of self-tolerance.
In a symptomatic patient, this result warrants further testing for specific autoantibodies, such as anti-dsDNA and anti-Smith, to refine the diagnosis. The homogeneous pattern suggests antibodies against chromatin or histones.
A low-positive ANA (e.g., 1:40 or 1:80) can occur in up to 15% of healthy individuals. Always correlate the titer and pattern with the patient's clinical presentation to avoid overdiagnosis.
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