A nurse is caring for a client prescribed Metoprolol. Which nursing action is most appropriate regarding checking heart rate and blood pressure prior to administration?
1血中濃度可能因尼古丁對肝臟酵素的競爭性抑制作用而下降，需較高劑量以維持治療效果
2血中濃度可能維持不變，因theophylline主要經腎臟排泄，而吸菸不會損害腎功能✓ 正確答案
3濃度可能上升到毒性範圍；通常需減量，因吸菸誘導CYP1A2而戒菸會使誘導作用消退
4血中濃度可能降至次治療濃度；因吸菸會抑制CYP1A2且戒菸會逆轉此抑制作用，故劑量通常需增加
解析
When administering Metoprolol, key nursing considerations include monitoring patient status, checking critical laboratory values, and providing appropriate safety education. Unsafe practices such as stopping medications abruptly or doubling missed doses are incorrect.