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心房顫動服用apixaban之病人末次劑量90分鐘後因腦內出血就醫。適當處置?複選。

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1 Administer protamine sulfate to neutralize the apixaban 給予protamine sulfate中和apixaban 2 Administer andexanet alfa as the targeted reversal agent for apixaban 給予andexanet alfa作為apixaban之標靶拮抗劑 3 Administer 4-factor prothrombin complex concentrate if andexanet is unavailable 若無andexanet,給予4因子PCC 4 Lower systolic blood pressure to a target around 140 mm Hg 將收縮壓降至約140 mmHg 5 Administer fresh frozen plasma 4 units as first-line reversal 以新鮮冷凍血漿4單位作為首選拮抗

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