# Situation: A 19-year-old man is admitted with dark, cola-colored urine, puffy eyelids on waking, and a blood pressure of 158/98 mmHg. Three weeks ago he had infected sores on his legs that healed without treatment. His anti-deoxyribonuclease B (anti-DNase B) titer is high and his serum complement (C3) is low. Acute post-streptococcal glomerulonephritis (PSGN) is diagnosed. On day 2 his blood pressure is 176/110 mmHg. Which finding should the nurse report to the provider at once?

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=629925  
> language: ko  
> subject: Nursing Practice III — Care of Clients with Problems in Surgery, Oxygenation, Fluid and Electrolytes, Infectious, Inflammatory and Immunologic Response, Cellular Aberrations

## 문제

Situation: A 19-year-old man is admitted with dark, cola-colored urine, puffy eyelids on waking, and a blood pressure of 158/98 mmHg. Three weeks ago he had infected sores on his legs that healed without treatment. His anti-deoxyribonuclease B (anti-DNase B) titer is high and his serum complement (C3) is low. Acute post-streptococcal glomerulonephritis (PSGN) is diagnosed.

On day 2 his blood pressure is 176/110 mmHg. Which finding should the nurse report to the provider at once?

## 보기

1. Cola-colored urine at the morning void
2. Puffy eyelids on waking that ease by noon
3. Severe headache with blurred vision **✔ 정답**
4. A small amount of protein on the urine dipstick

**정답: 3**

## 해설

Severe hypertension in acute glomerulonephritis can cause hypertensive encephalopathy, which begins with severe headache and visual change and can progress to confusion and seizures. Cola-colored urine, eyelid edema, and proteinuria are expected findings of post-streptococcal glomerulonephritis that are monitored but do not need immediate escalation.

## 심화 해설

Why the correct answer is a priority

On day 2 the blood pressure has risen from 158/98 mmHg to 176/110 mmHg. In acute post-streptococcal glomerulonephritis (PSGN), this degree of severe hypertension can overwhelm cerebral autoregulation and lead to hypertensive encephalopathy. The earliest clinical warning signs are a severe headache accompanied by visual disturbance such as blurred vision. If not reported immediately, this can progress to confusion, seizures, or posterior reversible encephalopathy syndrome (PRES) [1][2][3]. Therefore, severe headache with blurred vision is the finding that requires immediate escalation to the provider.

Understanding the underlying mechanism

PSGN follows a nephritogenic group A beta-hemolytic streptococcal infection, often of the skin or pharynx. The patient’s infected leg sores three weeks earlier, elevated anti-DNase B titer, and low serum C3 complement all support immune-complex-mediated glomerular injury. The resulting inflammation reduces glomerular filtration, causing sodium and water retention. This volume overload, combined with inappropriate renin-angiotensin-aldosterone activation, drives the severe hypertension seen in this patient.

When blood pressure rises rapidly, cerebral arterioles normally constrict to maintain constant cerebral perfusion. Beyond the upper limit of autoregulation, this protective vasoconstriction fails. The result is vasogenic edema in the posterior cerebral white matter, which is the hallmark of PRES [1][3]. The clinical presentation begins with headache and visual changes because the occipital and parietal lobes are most vulnerable [3][4].

| Finding | Clinical significance | Nursing action |
| --- | --- | --- |
| Severe headache with blurred vision | Early sign of hypertensive encephalopathy or PRES; may progress to seizure or coma [1][2][3] | Report immediately; anticipate antihypertensive therapy and neurologic monitoring |
| Cola-colored urine | Expected hematuria from glomerular inflammation | Monitor and document; no immediate escalation needed |
| Puffy eyelids that ease by noon | Expected periorbital edema from fluid retention | Monitor daily weight, intake and output, and sodium restriction |
| Small amount of protein on dipstick | Expected mild proteinuria in PSGN | Monitor trends; quantify with 24-hour collection if ordered |

Why the other options are not immediate concerns

Cola-colored urine reflects red blood cell casts and hemoglobin passing through damaged glomeruli. It is a classic and expected finding in PSGN and typically resolves as the glomerular inflammation subsides. It does not by itself indicate a neurologic emergency.

Puffy eyelids on waking are caused by dependent fluid accumulation in loose periorbital tissue during recumbency. The fact that the puffiness eases by noon indicates that it is gravitational edema, not an acute airway or anaphylactic problem. It is monitored through daily weights and fluid balance, but it does not require urgent provider notification.

A small amount of protein on the urine dipstick is anticipated because glomerular basement membrane damage permits albumin leakage. In PSGN, proteinuria is usually mild to moderate. It becomes a priority only if it is massive enough to suggest nephrotic syndrome, which is not described here.

Clinical correlation with PRES

PRES is a neuro-radiologic syndrome defined by headache, visual disturbance, seizures, and vasogenic edema on imaging [3]. Although PRES is rare in adult PSGN, case reports consistently describe it as a complication of severe or even mildly elevated blood pressure in this setting [2][3][4]. The key point for nursing assessment is that neurologic symptoms in a patient with acute glomerulonephritis and rising blood pressure must be treated as a hypertensive emergency until proven otherwise. A severe headache with blurred vision is the earliest and most reliable bedside indicator of impending neurologic deterioration.

Watch out! Do not wait for confusion or seizures to appear before reporting. Headache with visual change is already a red flag for cerebral edema and requires immediate intervention [1][3].

Key point! In PSGN, cola-colored urine, periorbital edema, and mild proteinuria are expected findings that are monitored. A new severe headache with blurred vision in the setting of worsening hypertension signals possible hypertensive encephalopathy or PRES and must be reported at once.References (research sources)

- [1]Post-streptococcal glomerulonephritis leading to posterior reversible encephalopathy syndrome: a case report.Case reportAdikari M, Priyangika D, Marasingha I, Thamotheram S, Premawansa G (2014) · DOI: 10.1186/1756-0500-7-644

- [2]Posterior reversible encephalopathy syndrome in adult acute post-streptococcal glomerulonephritis.Research articleHan Q, Zhu L (2025) · DOI: 10.1177/03000605251318851

- [3]Posterior Reversible Encephalopathy Syndrome Associated With Post-Streptococcal Glomerulonephritis in a Young Adult: A Case Report and Literature Review.Case reportDaoud MHS, Mohmed MHA, Ali SS, Mostafa A, Ibrahim KEM, Alqiwani RHS. (2026) · DOI: 10.12659/ajcr.952209

- [4]Posterior reversible encephalopathy syndrome secondary to acute post-streptococcal glomerulonephritis in a child: a case report from the Tibetan plateau.Case reportBazhu, Shi Y, Ren S, Shu L, Li Q (2022) · DOI: 10.1186/s12883-022-02750-x

## 임상 시나리오

PSGN: Recognizing Hypertensive EmergencyWhen to escalate immediately in acute glomerulonephritis
In acute post-streptococcal glomerulonephritis, worsening hypertension signals risk for hypertensive encephalopathy. Report immediately if blood pressure rises to 176/110 mmHg or higher with new severe headache or blurred vision.

Expected findings that require monitoring only include cola-colored urine, periorbital edema that improves by midday, and mild proteinuria. These reflect glomerular injury and fluid retention, not neurologic compromise.

CautionUntreated severe hypertension can progress from headache and visual change to confusion, seizures, or PRES. Do not wait for altered mental status before escalating.

## 핵심 개념

- **Hypertensive encephalopathy** — A neurologic emergency caused by severely elevated blood pressure that overwhelms cerebral autoregulation, leading to cerebral edema; early signs include severe headache and visual changes.
- **Acute post-streptococcal glomerulonephritis (PSGN)** — Immune-complex-mediated glomerular inflammation occurring 1-3 weeks after a nephritogenic group A beta-hemolytic streptococcal infection of the skin or pharynx.
- **Anti-DNase B titer** — A serologic marker indicating recent streptococcal infection, particularly useful when skin infection precedes PSGN.
- **Cerebral autoregulation** — The brain's ability to maintain constant blood flow despite changes in systemic blood pressure; fails when blood pressure exceeds the upper limit, causing vasogenic edema.
- **Posterior reversible encephalopathy syndrome (PRES)** — A clinical-radiologic syndrome of vasogenic edema, typically in the posterior cerebral white matter, caused by acute severe hypertension.

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