# Situation: A 26-year-old woman with systemic lupus erythematosus (SLE) comes to the medical outpatient clinic for follow-up. She takes hydroxychloroquine daily and prednisone 5 mg daily. Her usual blood pressure is 110/70 mmHg. Which instruction about hydroxychloroquine should the nurse give her?

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=629825  
> language: ko  
> subject: Nursing Practice III — Care of Clients with Problems in Surgery, Oxygenation, Fluid and Electrolytes, Infectious, Inflammatory and Immunologic Response, Cellular Aberrations

## 문제

Situation: A 26-year-old woman with systemic lupus erythematosus (SLE) comes to the medical outpatient clinic for follow-up. She takes hydroxychloroquine daily and prednisone 5 mg daily. Her usual blood pressure is 110/70 mmHg.

Which instruction about hydroxychloroquine should the nurse give her?

## 보기

1. Take it only during flares to limit its effect on her eyes
2. Take it daily even when well, and have regular eye checks **✔ 정답**
3. Stop it as soon as she starts planning to become pregnant
4. Stop it once her rash and joint pains have fully cleared

**정답: 2**

## 해설

Hydroxychloroquine is recommended for all clients with SLE because it reduces flares and improves survival, so it is taken daily even when the disease is quiet. Its main risk is retinal toxicity, so a baseline eye examination and yearly screening after 5 years are needed. It is continued during pregnancy because stopping it provokes flares.

## 심화 해설

Why hydroxychloroquine is taken continuously, not “as needed”

Hydroxychloroquine is not a quick symptom-reliever like a painkiller or a short steroid burst. In SLE, it works as a background immunomodulator that lowers overall disease activity. Stopping it when the rash or joint pain improves removes that protective effect, which is why it is continued even when the patient feels well. Hydroxychloroquine is recommended for all patients with SLE because it reduces flares and improves long-term survival, so daily use is the rule rather than the exception. The dose is typically kept at or below 5 mg/kg/day based on actual body weight, with adjustment if renal function declines [1].

Watch out! A common exam trap is the idea that hydroxychloroquine should be stopped once skin or joint symptoms resolve. That thinking applies to short-term symptom control, not to a disease-modifying agent in SLE. Stopping it during remission can trigger a flare.

Retinal toxicity: the reason for regular eye checks

The most important long-term risk of hydroxychloroquine is retinal toxicity, which can progress to irreversible vision loss if not caught early. The risk is not immediate; it accumulates over years. In one multinational SLE cohort, the prevalence of HCQ-related retinopathy reached 8.6–11.5% after 15 years of use [1]. Established risk modifiers include a higher daily dose relative to real body weight, longer duration or cumulative exposure, and renal impairment [2]. Because early retinal changes may be asymptomatic, screening is essential. A baseline eye examination is performed when treatment begins, and annual screening is recommended after 5 years of use—or sooner if additional risk factors are present [1][2].

Key point! The eye examination is not a reason to stop the drug preemptively. It is a monitoring strategy that allows the patient to keep receiving the benefits of hydroxychloroquine while detecting toxicity at a reversible or stable stage.

Why the other options are incorrect

| Option | Problem |
| --- | --- |
| 1. Take it only during flares to limit eye effects | Hydroxychloroquine is a maintenance drug, not a flare-only rescue therapy. Intermittent use removes its flare-prevention and survival benefit. |
| 3. Stop it as soon as she starts planning pregnancy | Hydroxychloroquine is continued during pregnancy because stopping it increases the risk of lupus flares, which are themselves harmful to both mother and fetus. |
| 4. Stop it once rash and joint pains have cleared | Symptom resolution does not mean the disease is inactive at the immunologic level. Discontinuation during clinical quiescence can provoke a flare. |

Clinical application for nursing care

When teaching a patient with SLE about hydroxychloroquine, the nurse should emphasize that the medication is taken daily regardless of how the patient feels, and that regular ophthalmology follow-up is part of safe long-term use. The patient in this scenario is on prednisone 5 mg daily in addition to hydroxychloroquine, which reflects a common maintenance regimen. The nurse can reinforce that hydroxychloroquine may allow a lower steroid dose over time, reducing steroid-related complications. The instruction that best captures both the daily-use principle and the monitoring requirement is to take it daily even when well and have regular eye checks.References (research sources)

- [1][Hydroxychloroquine in systemic lupus erythematosus: Key updates].Research articleTrefond L (2025) · DOI: 10.1016/j.revmed.2025.05.011

- [2]Hydroxychloroquine Retinopathy in Systemic Lupus Erythematosus: Risk Factors, Screening, and Emerging Biomarkers.Research articleTlaiss Y, Harajli A, Mashtoub EA, Nasreddine AS, Badawi T, Tarchichi A, Tlais M. (2026) · DOI: 10.1155/joph/8124348

## 임상 시나리오

Hydroxychloroquine in SLE: Daily Use and Eye SafetyMaintenance therapy, not a flare-only rescue drug
Teach the patient to take hydroxychloroquine daily even when well, because it reduces flares and improves survival as a background immunomodulator. It is not stopped when rash or joint pain clears.

Schedule a baseline eye examination and then yearly screening after 5 years of use. The main long-term risk is retinal toxicity, which can become irreversible if not detected early.

Keep the dose at or below 5 mg/kg/day based on actual body weight, with adjustment if renal function declines. Retinopathy prevalence may reach 8.6–11.5% after 15 years of use.

CautionDo not stop hydroxychloroquine when the patient starts planning pregnancy. Discontinuation can provoke SLE flares, so it is continued during pregnancy unless the rheumatologist directs otherwise.

## 핵심 개념

- **Hydroxychloroquine** — An immunomodulator used daily in SLE to reduce flares and improve survival; main long-term risk is retinal toxicity.
- **Retinal toxicity** — Dose- and duration-dependent ocular damage from hydroxychloroquine requiring baseline and periodic eye screening.
- **SLE maintenance therapy** — Continuous background treatment aimed at lowering overall disease activity, not just controlling acute symptoms.
- **Disease-modifying agent** — A drug that alters the underlying disease course rather than providing only short-term symptom relief.
- **Flares** — Episodes of increased SLE disease activity that hydroxychloroquine helps prevent when taken consistently.

## 같은 주제 문제

- [Situation: A 29-year-old woman has a pre-employment medical examination at a private manuf…](https://mymerci.kr/pages/nclex_q.php?qn_id=629716)
- [Situation: A 29-year-old woman has a pre-employment medical examination at a private manuf…](https://mymerci.kr/pages/nclex_q.php?qn_id=629717)
- [Situation: A 29-year-old woman has a pre-employment medical examination at a private manuf…](https://mymerci.kr/pages/nclex_q.php?qn_id=629718)
- [Situation: A 29-year-old woman has a pre-employment medical examination at a private manuf…](https://mymerci.kr/pages/nclex_q.php?qn_id=629719)
- [Situation: A 34-year-old man was diagnosed with human immunodeficiency virus (HIV) infecti…](https://mymerci.kr/pages/nclex_q.php?qn_id=629720)
- [Situation: A 34-year-old man was diagnosed with human immunodeficiency virus (HIV) infecti…](https://mymerci.kr/pages/nclex_q.php?qn_id=629721)
- [Situation: A 34-year-old man was diagnosed with human immunodeficiency virus (HIV) infecti…](https://mymerci.kr/pages/nclex_q.php?qn_id=629722)
- [Situation: A 41-year-old man is admitted to the medical ward with weakness that began in b…](https://mymerci.kr/pages/nclex_q.php?qn_id=629723)

---

More free questions: [기출문제](https://mymerci.kr/)

_학습 참고용입니다. 실제 임상은 최신 지침과 소속 기관 프로토콜을 따르세요._