# Situation: The nurse at a lying-in clinic holds a mothers' class for women between 28 and 36 weeks' gestation whose pregnancies have been uncomplicated. The class handout lists the approximate caffeine content of common drinks: 1 cup of brewed coffee, 100 mg; 1 sachet of instant coffee, 60 mg; 1 cup of tea, 40 mg; 1 can of cola, 35 mg. The handout advises keeping caffeine from all sources below 200 mg a day. Four participants describe what they plan to drink each day. Which plan shows correct understanding of the caffeine limit in pregnancy?

> source: MyMerci (mymerci.kr)  
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> subject: Nursing Practice II — Maternal and Child Health Nursing

## 문제

Situation: The nurse at a lying-in clinic holds a mothers' class for women between 28 and 36 weeks' gestation whose pregnancies have been uncomplicated.

The class handout lists the approximate caffeine content of common drinks: 1 cup of brewed coffee, 100 mg; 1 sachet of instant coffee, 60 mg; 1 cup of tea, 40 mg; 1 can of cola, 35 mg. The handout advises keeping caffeine from all sources below 200 mg a day. Four participants describe what they plan to drink each day. Which plan shows correct understanding of the caffeine limit in pregnancy?

## 보기

1. Three sachets of instant coffee and one can of cola
2. One cup of brewed coffee, one cup of tea and one can of cola **✔ 정답**
3. Two cups of tea, one sachet of instant coffee and two cans of cola
4. One cup of brewed coffee and two sachets of instant coffee

**정답: 2**

## 해설

Caffeine in pregnancy should stay under about 200 mg a day, counting every source, not only coffee. The totals are 215 mg (3 × 60 + 35), 220 mg (100 + 2 × 60), 210 mg (2 × 40 + 60 + 2 × 35), and 175 mg (100 + 40 + 35). Only the last plan stays under the limit.

## 심화 해설

Clinical context During pregnancy, caffeine crosses the placenta freely because it is lipophilic, and the fetus has very limited ability to metabolize it. The enzyme CYP1A2, which breaks down caffeine in the adult liver, is essentially absent in the fetal liver, so caffeine and its active metabolite paraxanthine remain in the fetal circulation much longer than in the mother. This is the core reason that even moderate maternal intake can produce sustained fetal exposure [1][2]. The widely accepted antenatal guidance is to keep total daily caffeine from all sources below 200 mg, a threshold that reflects the level below which most human studies have not shown consistent harm [4].

Step-by-step calculation The class handout gives fixed caffeine values, so the correct approach is to add every drink the participant plans to consume. The four plans produce the following totals.

| Plan | Drinks | Calculation | Total caffeine | Judgment |
| --- | --- | --- | --- | --- |
| 1 | Three sachets of instant coffee + one can of cola | (3 × 60) + 35 | 215 mg | Exceeds limit |
| 2 | One cup of brewed coffee + one cup of tea + one can of cola | 100 + 40 + 35 | 175 mg | Within limit |
| 3 | Two cups of tea + one sachet of instant coffee + two cans of cola | (2 × 40) + 60 + (2 × 35) | 210 mg | Exceeds limit |
| 4 | One cup of brewed coffee + two sachets of instant coffee | 100 + (2 × 60) | 220 mg | Exceeds limit |

Only plan 2 stays below the 200 mg threshold. The other three plans exceed it by 10 to 20 mg, which may seem small but is clinically meaningful because the recommendation is a ceiling, not a target. Pregnant women should not aim to get close to 200 mg; they should remain clearly under it, because caffeine content in real beverages varies by brewing method, cup size, and brand.

Why the limit is not just about coffee A common error is to count only coffee and ignore tea, cola, chocolate, energy drinks, and some over-the-counter analgesics. The class handout explicitly states that the limit applies to caffeine from all sources. Watch out! Tea and cola contribute meaningful amounts, and when combined with coffee they can push a seemingly moderate intake over the threshold. In plan 3, the two cans of cola alone provide 70 mg, which is more than one sachet of instant coffee.

Why fetal exposure matters Caffeine crosses the blood–brain barrier and the placental barrier, and it has been detected in amniotic fluid [2]. Because the fetus cannot clear caffeine efficiently, maternal plasma levels do not reflect fetal tissue exposure. This pharmacokinetic mismatch underlies the concern that repeated daily intake, even at levels that feel mild to the mother, may produce cumulative fetal exposure. Some cohort studies have reported reduced neonatal anthropometric measurements with higher maternal caffeine consumption, although the evidence is not uniform [2]. The 200 mg limit is therefore a precautionary threshold intended to keep fetal exposure low rather than to identify a precise toxic dose [4].

Test-taking strategy For calculation questions like this, the safest approach is to compute every option before selecting an answer. Key point! The correct option is the only one that is below 200 mg; the distractors are designed to be close to the limit, so rounding or estimating can lead to an incorrect choice. Write out the arithmetic for each option, then compare each total against the fixed cutoff. Also note that the question asks which plan shows correct understanding, meaning the participant must account for all drinks, not just the coffee-based ones. This reflects the broader nursing teaching point: caffeine education in pregnancy must include hidden and non-coffee sources, because total daily intake is what determines risk [1][4].References (research sources)

- [1]Pregnancy and Caffeine Metabolism: Updated Insights and Implications for Maternal-Fetal Health.Research articleStruniewicz KM, Ptaszek MM, Ziółkowska AM, Nitsch-Osuch A, Kozłowska A. (2025) · DOI: 10.3390/nu17193173

- [2]The Fetal Effect of Maternal Caffeine Consumption During Pregnancy-A Review.Research articleDube R, Kar SS, Bahutair SNM, Kuruba MGB, Shafi S, Zaidi H (2025) · DOI: 10.3390/biomedicines13020390

- [4]Assessment of Caffeine Consumption and Maternal Cardiometabolic Pregnancy Complications.Research articleHinkle SN, Gleason JL, Yisahak SF, Zhao SK, Mumford SL, Sundaram R (2021) · DOI: 10.1001/jamanetworkopen.2021.33401

## 임상 시나리오

Prenatal Caffeine LimitKeep total daily intake below 200 mg
Caffeine crosses the placenta because it is lipophilic, and the fetal liver lacks CYP1A2, so caffeine and paraxanthine remain in fetal circulation much longer than in the mother.

The recommended ceiling is 200 mg of caffeine per day from all sources, not only coffee. Add every drink and food item containing caffeine when estimating intake.

Using the class handout values, one cup of brewed coffee (100 mg) plus one cup of tea (40 mg) plus one can of cola (35 mg) totals 175 mg, which is the only plan below the limit.

CautionThe 200 mg limit is a ceiling, not a target. Plans exceeding it by even 10–20 mg are clinically meaningful because fetal clearance is markedly slower.

## 핵심 개념

- **Caffeine** — A lipophilic stimulant that crosses the placenta; fetal metabolism is limited due to absent CYP1A2.
- **CYP1A2** — The main hepatic enzyme that metabolizes caffeine in adults; essentially absent in the fetal liver.
- **Paraxanthine** — The primary active metabolite of caffeine, which also accumulates in the fetal circulation.
- **Antenatal guidance** — Recommendation to keep total daily caffeine intake below 200 mg from all sources.
- **Total daily caffeine** — The sum of caffeine from coffee, tea, cola, chocolate, and other dietary sources.

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