# During peripheral doxorubicin infusion, a client develops new burning and stinging, localized erythema, a 3 cm area of swelling, and a high-pressure pump alarm at the IV site. Blood return remains present on gentle aspiration; temperature is 36.9 C and the client has no dyspnea. Which actions should the nurse include in the immediate extravasation response? Select exactly 4 responses.

> source: MyMerci (mymerci.kr)  
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> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

During peripheral doxorubicin infusion, a client develops new burning and stinging, localized erythema, a 3 cm area of swelling, and a high-pressure pump alarm at the IV site. Blood return remains present on gentle aspiration; temperature is 36.9 C and the client has no dyspnea. Which actions should the nurse include in the immediate extravasation response? Select exactly 4 responses.

Select exactly 4 responses.

1

Stop the doxorubicin infusion and disconnect the administration tubing.

2

Activate the oncology extravasation protocol and prepare for dexrazoxane when prescribed.

3

Leave the catheter in place temporarily to aspirate residual drug without flushing.

4

Remove the catheter immediately after stopping the infusion, before attempting to aspirate residual drug.

5

Apply a warm compress to disperse doxorubicin before the prescribed antidote is started.

6

Apply intermittent ice and elevate the affected extremity.

## Explanation

Appropriate actions stop doxorubicin exposure, preserve the catheter briefly for aspiration without flushing, apply intermittent cold and elevation, and activate the extravasation protocol for timely dexrazoxane when prescribed. A warm compress can increase local dispersion of an anthracycline vesicant, and removing the catheter before aspiration eliminates the access needed to withdraw residual drug.

## In-depth explanation

Quick answer
Choose stopping, aspiration without flushing, intermittent ice with elevation, and rapid protocol activation.

Why this is correct
The doxorubicin label directs clinicians to avoid flushing and pressure, apply ice, elevate an affected extremity, and consider dexrazoxane. Timely team activation is necessary because the first antidote infusion must begin within 6 hours.

Easy analogy or mental picture
Contain, recover, cool, and escalate; do not spread the spill.

Memory hook
No flush, no pressure, and no delay for anthracycline extravasation.

NCLEX decision rule
Generate actions that reduce further exposure and preserve time-sensitive treatment options.

Why the other choices are wrong
Massage and pressure may worsen local distribution. Flushing can move retained vesicant into the tissue.References
1DailyMed: Doxorubicin Extravasation ManagementAspiration, no flushing, ice, elevation, and dexrazoxane consideration
2FDA: Totect Prescribing InformationAnthracycline extravasation treatment within 6 hours and renal dose modification
3ONS/ASCO Antineoplastic Extravasation GuidelineEvidence-based antidote, thermal care, and escalation framework

## Clinical scenario

Doxorubicin extravasation solution set
Combine exposure control, aspiration, drug-specific local care, documentation, and time-sensitive antidote escalation.

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