# A nurse is caring for a patient who has been taking lorazepam (Ativan) 2 mg three times daily for anxiety for the past 6 months. The patient wants to discontinue the medication. What is the most important nursing action? > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=543531 > language: ko > subject: Pharmacology ## 문제 A nurse is caring for a patient who has been taking lorazepam (Ativan) 2 mg three times daily for anxiety for the past 6 months. The patient wants to discontinue the medication. What is the most important nursing action? ## 보기 1. Advise the patient to stop the medication immediately to avoid dependency 2. Collaborate with the healthcare provider to develop a gradual tapering schedule **✔ 정답** 3. Recommend switching to an over-the-counter sleep aid 4. Suggest the patient take the medication only when feeling anxious **정답: 2** ## 해설 Long-term benzodiazepine use requires gradual tapering to prevent dangerous withdrawal symptoms like seizures. Collaborating with the provider for a tapering schedule is the priority action. Other options (abrupt stop, OTC switch, PRN use) are inappropriate and risky. ## 심화 해설 Understanding the Clinical Scenario The patient has been on a consistent, long-term regimen of lorazepam (Ativan), a benzodiazepine, for six months. The key concept here is physical dependence, which is an expected neurobiological adaptation that occurs with regular benzodiazepine use, distinct from addiction. After half a year of daily dosing, the patient's central nervous system has become physiologically accustomed to the drug's presence to maintain homeostasis. The most important nursing action is to ensure patient safety by preventing a severe withdrawal syndrome, which can be life-threatening. Why Immediate Discontinuation is Dangerous Advising the patient to stop the medication immediately (Option 1) or to switch to an over-the-counter sleep aid (Option 3) is contraindicated and hazardous. Abrupt cessation of a benzodiazepine after prolonged use can precipitate a severe withdrawal syndrome. The clinical practice guideline on benzodiazepine tapering explicitly notes that discontinuation can be difficult and is often unsuccessful because withdrawal symptoms can be severe and long-lasting, especially after long-term use [3]. These symptoms are not merely a return of anxiety but a physiological hyperexcitability of the central nervous system, which can include seizures, psychosis, and delirium. An over-the-counter sleep aid, often containing antihistamines, does not act on the same GABA_A receptor complex and will not prevent this dangerous withdrawal state. The Rationale for a Gradual Tapering Schedule Collaborating with the healthcare provider to develop a gradual tapering schedule (Option 2) is the evidence-based standard of care. The goal of tapering is to slowly reverse the neuroadaptations that have occurred, allowing the patient's own neurotransmitter systems to regain equilibrium. The multi-disciplinary expert panel recommendations emphasize that standard tapering protocols may fail or result in harm from improper utilization of pharmacologic principles [2]. This highlights the need for an individualized plan, not a one-size-fits-all approach. The most current pharmacological principles support proportionate reductions, such as 5%-10% of the most recent dose, rather than fixed linear reductions, to minimize discomfort and improve the chances of successful deprescribing [3]. A nurse's role is to advocate for this safe, evidence-based approach by initiating the collaboration with the provider. Why PRN Dosing is Inappropriate at This Stage Suggesting the patient take the medication only when feeling anxious (Option 4) undermines the physiological basis of tapering. A PRN (as needed) schedule creates inconsistent blood levels, which can lead to interdose withdrawal and kindling, a process where each withdrawal episode becomes progressively more severe. Successful deprescribing requires a predictable, steady reduction in receptor occupancy, which is only achievable with a scheduled, gradual taper. The D-PRESCRIBE intervention, a pharmacist-led deprescribing model, reinforces this by using structured communication tools and educational materials to guide a systematic, planned reduction, not an erratic, symptom-driven dosing pattern . The foundational principle from the ASAM guideline is that a deliberate, collaborative taper is necessary when the risks of continued use outweigh the benefits .References (research sources) - [2]Benzodiazepine receptor agonist deprescribing principles for long-term use and dependence: modified Delphi recommendations from a multi-disciplinary expert panel.GuidelineBrandt J, Lamberson N, Bressi J, Ritvo A, Curle J, Witt-Doerring J, DeWert M, Wright S, Horowitz M. (2026) · DOI: 10.1177/20451253261457547 - [3]Pharmacological principles for safe benzodiazepine and Z-drug dose reduction.Research articleHorowitz M, Lamberson N, Brandt J, Framer A, Shapiro B, Sørensen A, Cadogan C, Ritvo A, Taylor D. (2026) · DOI: 10.1017/s0033291726104887 ## 임상 시나리오 Benzodiazepine Tapering ProtocolPreventing Life-Threatening Withdrawal For a patient on lorazepam for 6 months, abrupt cessation is contraindicated due to physical dependence. The priority is to collaborate with the provider for a gradual tapering schedule. Withdrawal symptoms arise from CNS hyperexcitability and can include seizures, psychosis, and delirium. These are distinct from a return of baseline anxiety. CautionNever recommend immediate discontinuation or substitution with OTC sleep aids (antihistamines), as they do not act on GABA-A receptors and will not prevent a withdrawal crisis. ## 핵심 개념 - **Benzodiazepine Withdrawal Syndrome** — A potentially life-threatening state of CNS hyperexcitability (seizures, psychosis, delirium) occurring upon abrupt cessation after prolonged use. - **Physical Dependence** — A neurobiological adaptation to a drug's presence, requiring continued use to prevent withdrawal symptoms; distinct from addiction. - **GABA-A Receptor** — The primary inhibitory receptor in the CNS where benzodiazepines bind to enhance the effect of GABA, leading to sedation and anxiolysis. - **Tapering** — A gradual reduction of medication dosage over time to allow physiological adaptation and minimize withdrawal symptoms. ## 같은 주제 문제 - [A nurse is caring for a client who has been prescribed lorazepam (Ativan) for anxiety. 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