# A nurse is caring for a 55-year-old patient with heart failure who has been receiving digoxin 0.125 mg daily for the past 3 months. During the morning assessment, which finding should prompt the nurse to hold the medication and notify the healthcare provider immediately? > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=543513 > language: ko > subject: Pharmacology ## 문제 A nurse is caring for a 55-year-old patient with heart failure who has been receiving digoxin 0.125 mg daily for the past 3 months. During the morning assessment, which finding should prompt the nurse to hold the medication and notify the healthcare provider immediately? A 68-year-old patient with heart failure has been receiving digoxin 0.25 mg daily for the past 6 months. During the morning assessment, which finding should prompt the nurse to hold the medication and notify the healthcare provider immediately? ## 보기 1. Serum digoxin level of 2.8 ng/mL with nausea and visual disturbances **✔ 정답** 2. Heart rate of 68 beats per minute with a regular rhythm 3. Serum potassium level of 4.2 mEq/L with no symptoms 4. Blood pressure of 110/70 mmHg with no dizziness **정답: 1** ## 해설 Serum digoxin level of 2.8 ng/mL exceeds the therapeutic range and combined with nausea and visual disturbances indicates digoxin toxicity requiring immediate intervention. Other options represent normal or expected findings. ## 심화 해설 Clinical Context — Digoxin in Heart Failure Digoxin is a cardiac glycoside used for rate control in atrial fibrillation and to improve contractility in heart failure. It has a notoriously narrow therapeutic window, meaning the margin between an effective dose and a toxic dose is very small. Standard therapeutic serum concentrations typically range from 0.5 to 2.0 ng/mL. Toxicity can occur even at levels previously considered therapeutic, especially in the presence of electrolyte imbalances, renal impairment, or drug interactions [1]. Option Analysis — Why Option 1 is Correct The finding that requires immediate action is a serum digoxin level of 2.8 ng/mL accompanied by nausea and visual disturbances. This combination represents a classic presentation of digoxin toxicity. The serum level exceeds the therapeutic threshold, and the presence of gastrointestinal symptoms (nausea) alongside neurological symptoms (visual disturbances) indicates systemic toxicity that can rapidly progress to life-threatening cardiac arrhythmias. Current evidence confirms that digoxin toxicity can manifest with severe side effects, including life-threatening arrhythmias, and that management decisions must integrate both serum concentrations and clinical symptomatology [1]. Visual disturbances are a hallmark neurological manifestation; case reports describe patients experiencing photopsia (seeing sparkles of light) and other sensory disturbances as direct consequences of toxic digoxin levels [2]. Holding the medication and notifying the healthcare provider immediately is the correct nursing intervention to prevent deterioration. Why the Other Options Are Incorrect - Option 2: A heart rate of 68 beats per minute with a regular rhythm is a normal finding. While digoxin can cause bradycardia, a rate of 68 bpm is within the normal adult range and does not meet the typical threshold (often below 60 bpm) for holding the medication. This finding does not indicate toxicity. - Option 3: A serum potassium level of 4.2 mEq/L is within the normal reference range. Hypokalemia is a significant risk factor that potentiates digoxin toxicity, but this patient's potassium level is normal and there are no symptoms. This finding is not concerning in isolation. - Option 4: A blood pressure of 110/70 mmHg without dizziness is a stable, normotensive reading. While digoxin toxicity can cause hemodynamic instability, this blood pressure is well within acceptable limits and does not warrant holding the medication. Pathophysiology and Clinical Reasoning Digoxin exerts its therapeutic and toxic effects primarily by inhibiting the Na⁺/K⁺-ATPase pump on myocardial cells. At toxic levels, excessive inhibition leads to intracellular sodium accumulation, which alters the sodium-calcium exchanger, causing intracellular calcium overload. This mechanism increases automaticity and can trigger dangerous arrhythmias such as accelerated idioventricular rhythm (AIVR), as documented in cases where toxicity occurred even when serum levels appeared therapeutic due to sampling timing errors or drug interactions . The gastrointestinal symptoms (nausea, vomiting, anorexia) and neurological symptoms (visual disturbances including altered color perception, photopsia, or phantosmia) are early warning signs that precede cardiac manifestations. Recognizing these prodromal symptoms is critical because they provide a window for intervention before malignant arrhythmias develop [2]. In patients with renal impairment, the risk is magnified because digoxin is primarily cleared by the kidneys; reduced clearance leads to tissue accumulation and prolonged toxicity, which can be resistant to standard treatment with digoxin-specific antibody fragments . Nursing Implications for NCLEX-RN The NCLEX-RN frequently tests the recognition of digoxin toxicity because it requires the nurse to synthesize laboratory data with clinical assessment findings. The key principle is that the nurse must hold the medication and notify the provider when both toxic serum levels and symptoms are present. Always check the apical pulse for a full minute before administration; however, heart rate alone is insufficient to rule out toxicity, as dangerous rhythms like AIVR can occur with rates that are not profoundly bradycardic . Assess for visual disturbances, gastrointestinal symptoms, and neurological changes. Monitor serum digoxin levels, but remember that the timing of the blood draw relative to the last dose is critical — samples drawn too soon or too late after dosing can yield misleading results that do not reflect true tissue concentrations . Electrolyte monitoring, particularly potassium and magnesium, is essential because hypokalemia and hypomagnesemia sensitize the myocardium to digoxin's toxic effects. In patients with chronic kidney disease, the risk of accumulation and rebound toxicity after antidote administration is heightened due to impaired clearance of digoxin-Fab complexes . References (research sources) - [1]Digoxin toxicity with therapeutic serum digoxin concentrations.Research articleGraafsma J, Cimic N, Dijkman M, Gresnigt FMJ, Mitrovic D, Smit C. (2025) · DOI: 10.1016/j.toxrep.2025.102079 - [2]Floral phantosmia and bradycardia: A unique case of digoxin toxicity in an elderly patient.Research articleKasa M, Elezi B, Sinamati E, Spahia N, Rroji M. (2025) · DOI: 10.4103/tjem.tjem_275_24 ## 임상 시나리오 Digoxin Toxicity: Nursing Assessment & InterventionRecognizing and responding to a high-risk medication event Hold digoxin and notify the provider immediately for any confirmed or suspected toxicity. The hallmark presentation combines a supratherapeutic level (above 2.0 ng/mL) with clinical symptoms like nausea, vomiting, anorexia, or visual disturbances (blurred or yellow vision). Before each dose, always assess the apical pulse for a full minute. Withhold the drug for a heart rate below 60 bpm in adults and notify the provider. Monitor serum electrolytes, as hypokalemia (potassium below 3.5 mEq/L) and hypomagnesemia significantly increase the risk of toxicity. CautionA "normal" serum level does not rule out toxicity if symptoms are present, especially with electrolyte imbalances. Conversely, an elevated level without symptoms still requires immediate intervention. The antidote, digoxin immune Fab, is reserved for life-threatening toxicity. ## 핵심 개념 - **Digoxin Toxicity** — A potentially life-threatening condition resulting from excessive digoxin levels, characterized by gastrointestinal, neurological, and cardiac symptoms due to the drug's narrow therapeutic index. - **Therapeutic Drug Monitoring** — The clinical practice of measuring specific drug levels in the blood to maintain a constant therapeutic concentration, crucial for drugs with a narrow therapeutic window like digoxin. - **Narrow Therapeutic Index** — A small margin between a drug's effective dose and a toxic dose, requiring careful dosing and monitoring to avoid adverse effects. ## 같은 주제 문제 - [A nurse is caring for a patient receiving digoxin therapy. Which assessment finding would …](https://mymerci.kr/pages/nclex_q.php?qn_id=543512) - [A nurse is caring for a patient receiving digoxin therapy. 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