# A 32-year-old woman at 38 weeks gestation suddenly develops severe dyspnea, hypotension, and altered mental status during labor. The fetal heart rate shows severe bradycardia. Anaphylactoid syndrome of pregnancy (ASP) is suspected. What is the nurse's priority intervention?

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> subject: Maternal Newborn Health

## 문제

A 32-year-old woman at 38 weeks gestation suddenly develops severe dyspnea, hypotension, and altered mental status during labor. The fetal heart rate shows severe bradycardia. Anaphylactoid syndrome of pregnancy (ASP) is suspected. What is the nurse's priority intervention?

## 보기

1. Prepare for immediate cesarean delivery while initiating cardiopulmonary resuscitation **✔ 정답**
2. Administer high-flow oxygen and establish large-bore IV access for fluid resuscitation
3. Position the patient in left lateral decubitus and monitor vital signs closely
4. Obtain blood samples for coagulation studies and prepare for blood transfusion

**정답: 1**

## 해설

Immediate cesarean delivery is the priority to remove the source of amniotic fluid embolism and allow effective maternal resuscitation. Other interventions like oxygen or fluid resuscitation are important but do not address the underlying cause.

## 심화 해설

Understanding Anaphylactoid Syndrome of Pregnancy (ASP)

Anaphylactoid syndrome of pregnancy, historically referred to as amniotic fluid embolism (AFE), is a rare, catastrophic obstetric emergency. The classic triad involves sudden onset of respiratory distress, cardiovascular collapse (hypotension, cardiac arrest), and coagulopathy. The underlying mechanism is not a true embolic event, but rather an anaphylactoid reaction to fetal antigens entering the maternal circulation, triggering a massive systemic inflammatory response. This leads to pulmonary vasospasm, right heart failure, and left ventricular dysfunction, rapidly progressing to cardiorespiratory arrest. The case reports you see in the provided literature consistently highlight this abrupt presentation of severe dyspnea, hypotension, and altered mental status during labor or immediately postpartum [1,3,4].

Prioritizing Immediate Intervention

In a maternal cardiac arrest scenario, especially when fetal bradycardia is present, the guiding principle is maternal resuscitation. The pregnant uterus compresses the aorta and inferior vena cava, significantly impeding venous return and reducing the effectiveness of chest compressions. Therefore, the single most critical, time-sensitive intervention that directly impacts both maternal and fetal survival is to relieve this aortocaval compression while simultaneously initiating high-quality cardiopulmonary resuscitation (CPR). This is achieved by preparing for an immediate cesarean delivery, also known as a perimortem cesarean section. The literature underscores that in cases of AFE leading to cardiac arrest, prompt delivery is integral to the resuscitation effort, as it removes the source of the anaphylactoid trigger and optimizes maternal hemodynamics for CPR [3,4]. A case report explicitly describes a patient who developed cardiac arrest during emergency cesarean section for AFE, illustrating that surgical intervention is not a separate step but a concurrent, life-saving component of the resuscitation algorithm [4].

Analysis of Other Options

While the other options represent important aspects of care, they are not the immediate priority in the context of cardiac arrest with fetal bradycardia.

- Administering high-flow oxygen and establishing IV access is a critical component of initial stabilization for a patient in respiratory distress, but it is insufficient and delays definitive action once cardiac arrest has occurred or is imminent. The case reports detail that these patients rapidly deteriorate, and supportive measures alone do not reverse the underlying crisis [1,2].

- Positioning in left lateral decubitus is a standard intervention to relieve aortocaval compression in a conscious, hypotensive pregnant patient. However, in a full cardiac arrest scenario, this position makes effective chest compressions impossible. The definitive way to relieve compression during CPR is to empty the uterus.

- Obtaining coagulation studies and preparing for transfusion addresses the disseminated intravascular coagulation (DIC) that frequently complicates AFE, as noted in the case reports where massive hemorrhage followed the initial event [1,4]. However, managing DIC is a secondary priority; the immediate threat to life is the cessation of cardiac output and oxygenation, which must be corrected first to give any subsequent interventions a chance to succeed.References (research sources)

- [4]Amniotic Fluid Embolism Complicated with Hepatic Rupture: A Case Report.Case reportXu Y, Zhang Y, Zheng J, Chen C, Xu X, Yan J. (2025) · DOI: 10.2147/ijwh.s549171

## 임상 시나리오

Clinical Practice Guide: Anaphylactoid Syndrome of Pregnancy (ASP)

Rapid Recognition

- **Classic Triad:** Sudden onset of respiratory distress, cardiovascular collapse (hypotension, cardiac arrest), and coagulopathy during labor, delivery, or immediately postpartum.

- **Key Triggers:** Labor, cesarean section, placental abruption, uterine rupture. Presentation is abrupt with severe dyspnea, altered mental status, and fetal bradycardia.

Immediate Resuscitation Protocol

- **Activate Emergency Response:** Call for obstetrics, anesthesia, neonatology, and critical care teams simultaneously.

- **Initiate High-Quality CPR:** Begin chest compressions immediately. Displace the uterus manually to the left to partially relieve aortocaval compression.

- **Prepare for Perimortem Cesarean Delivery:** If no return of spontaneous circulation (ROSC) within 4 minutes of cardiac arrest, initiate the cesarean. The goal is to deliver the fetus within 5 minutes of arrest to maximize maternal and neonatal outcomes.

- **Airway Management:** Secure the airway with endotracheal intubation. Administer 100% oxygen. Avoid excessive ventilation.

- **Vascular Access and Fluids:** Establish two large-bore IV lines. Administer crystalloid boluses while avoiding volume overload that can worsen right heart strain.

Post-Resuscitation Priorities

- **Hemorrhage Control:** Anticipate massive hemorrhage due to DIC. Administer massive transfusion protocol with balanced ratios of packed RBCs, fresh frozen plasma, and platelets.

- **Hemodynamic Support:** Use vasopressors (e.g., norepinephrine) and inotropes (e.g., dobutamine) to manage cardiogenic shock and right ventricular failure.

- **Coagulopathy Management:** Send STAT labs (CBC, coagulation panel, fibrinogen). Replace fibrinogen aggressively if levels are critically low. Consider tranexamic acid.

- **Transfer to ICU:** Continuous monitoring for ongoing bleeding, organ failure, and neurological status.

Nursing Considerations

- **Documentation:** Meticulously document the time of arrest, initiation of CPR, time of delivery, medications administered, and estimated blood loss.

- **Family Support:** Assign a team member to communicate with the family, providing clear, compassionate updates on the rapidly evolving situation.

- **Debriefing:** Facilitate a team debrief after the event to address emotional impact and review performance.

## 핵심 개념

- **Anaphylactoid Syndrome of Pregnancy** — Pregnancy anaphylactoid syndrome. An acute, severe anaphylactoid-like reaction caused by amniotic fluid or fetal cellular components entering the maternal circulation. Previously called 'Amniotic Fluid Embolism'.
- **Disseminated Intravascular Coagulation** — Disseminated intravascular coagulation. A common complication in the second stage of ASP, this is a fatal coagulation disorder characterized by widespread microvascular thrombosis and a simultaneous bleeding tendency.
- **Maternal Cardiovascular Collapse** — Maternal cardiovascular collapse. A state of acute circulatory failure accompanied by severe hypotension, decreased consciousness, and reduced peripheral perfusion. An early major symptom of ASP.
- **Perimortem Cesarean Delivery** — Cesarean section performed just before or immediately after death. An emergency cesarean section performed to deliver the fetus and improve maternal resuscitation efficiency during or immediately after maternal cardiac arrest. A concept applied in situations such as ASP.
- **Fetal Bradycardia** — Fetal bradycardia. A condition where the fetal heart rate is persistently below the normal baseline (usually 110 bpm). An important indicator of fetal hypoxia and distress.

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