# A 58-year-old client with type 2 diabetes mellitus is scheduled for fluorescein angiography to assess for diabetic retinopathy progression. Which instruction should the nurse provide to the client before the procedure?

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## 문제

A 58-year-old client with type 2 diabetes mellitus is scheduled for fluorescein angiography to assess for diabetic retinopathy progression. Which instruction should the nurse provide to the client before the procedure?

A 58-year-old client with type 2 diabetes mellitus is scheduled for fluorescein angiography to assess for diabetic retinopathy progression.

## 보기

1. Inform the healthcare provider of any history of kidney stones
2. Inform the healthcare provider of any history of glaucoma
3. Inform the healthcare provider of any allergies, especially to iodine or shellfish **✔ 정답**
4. Inform the healthcare provider of any history of cataracts

**정답: 3**

## 해설

Informing about allergies, especially to iodine or shellfish, is crucial due to risk of allergic reactions to fluorescein dye. Other instructions like fasting or avoiding bright lights are not typically required.

## 심화 해설

Understanding Fluorescein Angiography

Fluorescein angiography is a diagnostic procedure used to evaluate the blood vessels in the retina and choroid. A water-soluble dye called fluorescein is injected intravenously, typically into an arm vein. As the dye circulates through the retinal vasculature, a specialized camera with appropriate filters takes serial photographs. This allows the healthcare provider to visualize blood flow, identify areas of ischemia, detect microaneurysms, and pinpoint abnormal vessel growth such as neovascularization, which is a hallmark of proliferative diabetic retinopathy [1]. The procedure is critical for staging diabetic retinopathy and guiding treatment decisions to prevent vision loss.

Analyzing the Correct Instruction

The most critical pre-procedure safety check is a thorough allergy assessment, making option 3 the correct instruction. The nurse must specifically ask about allergies, with a focus on iodine and shellfish.

**Why the focus on iodine and shellfish?**

This is a common point of confusion. The fluorescein dye used in this procedure is **not** an iodine-based radiocontrast agent like those used in CT scans or cardiac catheterization. However, a documented allergy to iodine or shellfish is a crucial piece of information to report. The clinical significance lies in the fact that a history of a severe anaphylactic reaction to any substance identifies a patient who is at a generally higher risk for hypersensitivity reactions to other injectable agents, including fluorescein. While the molecular structures are different, the patient's predisposition to a severe immune response is the key safety concern. The healthcare provider will use this information to weigh the risks and benefits, and to ensure that emergency resuscitative equipment and medications are readily available before proceeding.

Why Other Options Are Not the Priority

**Option 1: Inform the healthcare provider of any history of kidney stones.**

This is not a primary concern for fluorescein angiography. Fluorescein dye is primarily metabolized by the liver and excreted by the kidneys, but it is not nephrotoxic and does not carry the same risk of contrast-induced nephropathy as iodinated contrast media. A history of kidney stones is not a contraindication to the procedure.

**Option 2: Inform the healthcare provider of any history of glaucoma.**

A history of glaucoma is important for many eye examinations, particularly those involving pupil dilation. While the pupil is often dilated for fluorescein angiography to improve the view of the retina, the procedure itself does not involve injecting dye into the eye or increasing intraocular pressure. The dye is injected into a peripheral vein, making a history of glaucoma a less critical pre-procedure safety check compared to a potential for an anaphylactic reaction.

**Option 4: Inform the healthcare provider of any history of cataracts.**

A cataract is an opacification of the eye's natural lens. While a dense cataract can physically obstruct the clinician's view of the retina, making the images harder to interpret, it does not pose a safety risk to the patient during the injection of the fluorescein dye. This is a consideration for image quality, not a pre-procedure safety instruction that takes precedence over allergy assessment.

The core nursing responsibility before any procedure involving an injectable agent is to identify potential risks for a hypersensitivity reaction. A reported allergy to iodine or shellfish serves as a critical red flag for a patient who may be atopic and prone to severe reactions, necessitating heightened vigilance and preparation .References (research sources)

- [1]Ultra-widefield color fundus photography in diabetic retinopathy: from panretinal assessment to multimodal integration.Research articleFang R, Xu R, Wu Z, Tong Y. (2026) · DOI: 10.3389/fmed.2026.1845156

## 임상 시나리오

Fluorescein Angiography: Pre-Procedure Safety ScreeningCritical Allergy Assessment Before Dye Injection
The nurse must explicitly ask about any history of allergies, specifically to iodine or shellfish. Although fluorescein is not iodine-based, a prior severe anaphylactic reaction to any substance identifies a patient at high risk for hypersensitivity to the injectable dye.

Ensure the client understands the procedure: a water-soluble dye is injected intravenously, and a camera takes serial retinal photographs. The dye will temporarily discolor urine and skin to a yellow-orange hue for 24–36 hours.

CautionDo not confuse fluorescein with radiocontrast. Kidney stones and metformin use are not primary concerns here. The key safety step is ruling out a history of severe allergic reactions before injection.

## 핵심 개념

- **Fluorescein Angiography** — A diagnostic procedure using intravenous fluorescein dye and a specialized camera to visualize retinal and choroidal blood flow.
- **Anaphylactoid Reaction** — A severe, life-threatening hypersensitivity reaction that can occur upon exposure to an allergen, mimicking anaphylaxis but not always IgE-mediated.
- **Tracer Principle** — The use of a detectable substance introduced into a biological system to track its distribution, metabolism, or flow dynamics in real time.
- **Diabetic Retinopathy** — A diabetes complication affecting the eyes, caused by damage to the blood vessels of the light-sensitive tissue at the back of the eye (retina).

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