# A nurse is assessing a 35-year-old client who was admitted with suspected acute glomerulonephritis following a recent streptococcal throat infection. Which assessment finding would be most indicative of glomerular damage and require immediate nursing intervention? > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=541467 > language: ko > subject: Adult Health ## 문제 A nurse is assessing a 35-year-old client who was admitted with suspected acute glomerulonephritis following a recent streptococcal throat infection. Which assessment finding would be most indicative of glomerular damage and require immediate nursing intervention? ## 보기 1. Presence of red blood cell casts in the urine with proteinuria and oliguria **✔ 정답** 2. Mild peripheral edema in the lower extremities with weight gain of 2 pounds 3. Blood pressure reading of 142/88 mmHg with mild headache 4. Decreased appetite with nausea and fatigue **정답: 1** ## 해설 Red blood cell casts with proteinuria and oliguria are pathognomonic for acute glomerulonephritis, indicating direct glomerular damage requiring immediate intervention. Other findings are nonspecific and less urgent. ## 심화 해설 Understanding the Pathophysiology Post-streptococcal glomerulonephritis (PSGN) is an immune-complex-mediated inflammatory response that occurs after a group A beta-hemolytic streptococcal infection. Rather than a direct bacterial invasion of the kidneys, the damage results from antigen-antibody complexes becoming trapped in the glomerular basement membrane. This triggers complement activation and an inflammatory cascade that increases capillary permeability and damages the filtration barrier. The hallmark of this glomerular injury is the disruption of the sieve-like structure of the glomerulus, which normally retains large proteins and blood cells within the circulation while filtering waste into the urine. When this barrier is compromised, red blood cells (RBCs) and protein leak into the tubular fluid. In the nephron, these RBCs become enmeshed with Tamm-Horsfall protein, forming distinctive red blood cell casts. Their presence is a highly specific marker of glomerular inflammation, as described in the nephritic urine sediment of the pediatric case in the provided report [1]. Simultaneously, the inflammatory swelling of the glomerular tufts reduces the surface area available for filtration, leading to a drop in the glomerular filtration rate (GFR). This manifests clinically as oliguria (urine output less than 400 mL/day in adults), which signals a critical decline in renal function and the risk of impending acute kidney injury (AKI), a severe complication also highlighted in the adult IRGN case presenting with marked oliguria and a serum creatinine of 10.89 mg/dL [2]. Analyzing the Answer Choices The correct answer is the assessment finding that directly reflects active glomerular inflammation and a failing kidney's inability to clear waste and maintain fluid balance. Correct Answer: Option 1 The triad of red blood cell casts, proteinuria, and oliguria is the classic presentation of acute nephritic syndrome and is the most direct evidence of severe glomerular damage. The casts confirm that the bleeding originates from the glomerulus itself. Proteinuria indicates a loss of the glomerular barrier's size and charge selectivity. Most critically, oliguria is a direct clinical sign of a significantly reduced GFR, which can rapidly progress to life-threatening complications such as fluid overload, pulmonary edema, and critical hyperkalemia, as seen in the case where a child with PSGN developed severe respiratory distress and a critically elevated potassium level [1]. This combination of findings signals an active, destructive process that demands immediate nursing intervention, including strict intake and output monitoring, daily weights, assessment for fluid volume excess, and notification of the healthcare provider for urgent medical management to prevent irreversible kidney damage . Why Other Options Are Less Indicative - Option 2: Mild peripheral edema and a 2-pound weight gain suggest fluid retention, a common finding in PSGN due to sodium and water retention. However, this is a secondary effect of the glomerular damage and is not specific to the active inflammatory process itself. While it requires monitoring, it lacks the urgency of findings that directly indicate active glomerular bleeding and a critical drop in GFR. - Option 3: A blood pressure of 142/88 mmHg with a mild headache indicates hypertension, another common clinical manifestation driven by fluid overload and renin-angiotensin-aldosterone system activation. This is a manageable complication and, while important, does not provide the same level of direct evidence of ongoing glomerular destruction and imminent renal failure as the urinary findings in Option 1. - Option 4: Decreased appetite, nausea, and fatigue are nonspecific constitutional symptoms of uremia that occur as nitrogenous waste products accumulate. These are late and generalized signs of advanced renal impairment. They do not offer the immediate, localized, and diagnostic evidence of active glomerular injury that RBC casts and oliguria provide, which are necessary for a prompt and targeted intervention.References (research sources) - [1]Post-streptococcal Glomerulonephritis Presenting With Acute Pulmonary Edema and Critical Hyperkalemia: A Rare Pediatric Case Report From Yemen.Case reportMohamed AAA, Ayish MKM, Muafa HM. (2026) · DOI: 10.1177/11795476261444444 - [2]Post-streptococcal infection-related glomerulonephritis presenting with acute kidney injury and severe hypoglycaemia in a patient with diabetes.Research articleSugiura T, Kawase MY, Ito S, Ueda R, Ozeki T, Yokoe Y, Yasuda K, Maruyama S. (2026) · DOI: 10.1007/s13730-026-01102-9 ## 임상 시나리오 Recognizing Active Glomerular InjuryKey Findings in Post-Streptococcal Glomerulonephritis The most specific indicator of active glomerular inflammation is the presence of red blood cell casts in the urine. This finding, combined with proteinuria, confirms a disrupted filtration barrier. Oliguria, defined as urine output less than 400 mL/day, signals a critical drop in the glomerular filtration rate. This requires immediate intervention to prevent acute kidney injury. CautionDo not rely solely on hypertension or mild edema to assess severity. These are secondary to fluid retention and do not directly confirm active glomerular bleeding or a rapid decline in renal function. ## 핵심 개념 - **Red Blood Cell Casts** — Cylindrical structures formed in the renal tubules when RBCs become trapped in a protein matrix, indicating glomerular inflammation and bleeding (glomerulonephritis). - **Oliguria** — Urine output less than 400 mL per day in adults, signaling a significant reduction in glomerular filtration rate and a risk for acute kidney injury. - **Post-Streptococcal Glomerulonephritis** — Immune-complex-mediated inflammation of the glomeruli occurring after infection with group A beta-hemolytic streptococcus, often presenting as nephritic syndrome. - **Nephritic Syndrome** — A clinical syndrome characterized by hematuria, variable proteinuria, oliguria, hypertension, and azotemia resulting from glomerular inflammation. - **Glomerular Filtration Rate** — The rate at which blood is filtered through the glomeruli; a critical drop in GFR leads to the accumulation of waste products and fluid imbalance. ## 같은 주제 문제 - [A nurse is assessing a 45-year-old client diagnosed with acute glomerulonephritis. 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