# A nurse is caring for a client who received a kidney transplant 6 months ago. The client reports fatigue, decreased urine output, and mild abdominal pain. Laboratory results show elevated serum creatinine (2.8 mg/dL) and BUN (45 mg/dL). What is the priority nursing intervention?

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## 문제

A nurse is caring for a client who received a kidney transplant 6 months ago. The client reports fatigue, decreased urine output, and mild abdominal pain. Laboratory results show elevated serum creatinine (2.8 mg/dL) and BUN (45 mg/dL). What is the priority nursing intervention?

## 보기

1. Increase the client's fluid intake to 3000 mL per day
2. Administer prescribed diuretics to improve urine output
3. Notify the transplant team immediately and prepare for possible biopsy **✔ 정답**
4. Encourage ambulation and deep breathing exercises

**정답: 3**

## 해설

Elevated creatinine and BUN with decreased urine output in a kidney transplant recipient indicates possible acute rejection, requiring immediate notification of the transplant team for evaluation and possible biopsy. Other options are supportive but not the priority.

## 심화 해설

Understanding the Clinical Presentation

The client is 6 months post-kidney transplant and now presents with fatigue, decreased urine output, and mild abdominal pain. The laboratory results reveal an elevated serum creatinine of 2.8 mg/dL and BUN of 45 mg/dL. This clinical picture—oliguria combined with a significant rise in serum creatinine from the patient's baseline—is a classic presentation of acute graft dysfunction. In the post-transplant setting, this must be treated as a medical emergency until proven otherwise, as it can indicate acute rejection, calcineurin inhibitor toxicity, or infection.

Why the Priority is Notifying the Transplant Team

The priority intervention is to notify the transplant team immediately and prepare for a possible biopsy. The rationale is rooted in the diagnostic standard of care for graft dysfunction. As highlighted in the provided evidence, percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction [1]. It is the definitive method to differentiate between the various causes of a rising creatinine, such as acute cellular rejection, antibody-mediated rejection, or drug toxicity. Delaying this diagnosis can lead to irreversible graft damage and loss. The nurse's role is to recognize these critical signs, advocate for the patient by ensuring the specialist team is alerted without delay, and prepare the patient physically and psychologically for a potential biopsy procedure.

Analysis of Incorrect Options

- Option 1: Increase fluid intake. While fluid management is important, arbitrarily increasing fluid intake to 3000 mL/day is contraindicated without knowing the precise cause of the decreased urine output. If the patient is in acute rejection or has acute tubular necrosis, aggressive fluid loading could lead to fluid volume overload, hypertension, and pulmonary edema, especially in a patient with compromised renal function. This is not the priority action before a diagnosis is established.

- Option 2: Administer prescribed diuretics. Administering diuretics to force urine output is a potentially harmful intervention that treats a symptom, not the cause. If the oliguria is due to a mechanical issue like a ureteral stricture or a large lymphocele, diuretics will be ineffective and may worsen pre-renal azotemia. The underlying pathology must be identified first.

- Option 4: Encourage ambulation and deep breathing exercises. These are routine postoperative or general wellness interventions. While they are part of a comprehensive care plan to prevent complications like atelectasis and deep vein thrombosis, they do not address the acute, life- and organ-threatening issue of a sharp decline in kidney function. This option fails to prioritize the most urgent physiological need.

Connecting to the Biopsy Procedure and Nursing Implications

Once the decision for a biopsy is made, nursing responsibilities shift to preparation and post-procedure monitoring. The study on biopsy complications notes that post-procedural bleeding is the most frequent complication, particularly in recipients with impaired renal function [1]. This directly applies to this client, whose creatinine is already significantly elevated. Therefore, the nurse must ensure pre-procedure labs (CBC, coagulation profile) are checked, informed consent is obtained, and the patient is instructed on what to expect. After the procedure, vital signs, urine output, and the biopsy site must be monitored frequently for signs of hemorrhage, which is the primary, immediate risk.References (research sources)

- [1]Bleeding prevention with desmopressin for allograft kidney biopsies: a double-blind randomized study.RCT/clinical trialPacini GS, Manfro AG, Schuchmann RA, Junior VCB, Perez AV, Schneider ET, Backes LLA, Steckert GV, Manfro RC, Bauer AC. (2026) · DOI: 10.1093/ckj/sfag083

## 임상 시나리오

Recognizing Acute Kidney Transplant RejectionKey Assessment Findings and Immediate Actions
A classic presentation of acute graft dysfunction includes fatigue, decreased urine output (oliguria), and mild abdominal pain over the graft site. Laboratory findings will show a significant rise from baseline in serum creatinine (e.g., 2.8 mg/dL) and BUN (e.g., 45 mg/dL).

The priority nursing intervention is to notify the transplant team immediately. The definitive diagnostic step is a percutaneous kidney allograft biopsy to differentiate between acute cellular rejection, antibody-mediated rejection, or drug toxicity. The nurse's role is to prepare the client physically and psychologically for this procedure.

CautionNever increase fluid intake or administer diuretics for oliguria in a transplant patient without a specific order from the transplant team, as this can cause fluid overload and delay life-saving treatment for rejection.

## 핵심 개념

- **Acute Graft Dysfunction** — A sudden decline in the function of a transplanted organ, indicated by rising creatinine and decreased urine output, which is a medical emergency until proven otherwise.
- **Percutaneous Kidney Allograft Biopsy** — The gold standard diagnostic procedure for evaluating the cause of kidney transplant dysfunction, used to differentiate rejection from other causes like drug toxicity.
- **Serum Creatinine** — A waste product from muscle metabolism; elevated levels (e.g., 2.8 mg/dL) indicate impaired kidney function and are a key marker for graft rejection.
- **Oliguria** — Decreased urine output, often defined as less than 400 mL per day in adults, a critical sign of kidney injury or graft failure in transplant patients.

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