# A nurse is caring for a client with severe combined immunodeficiency (SCID) who has been admitted for a bone marrow transplant. Which nursing intervention is the highest priority for this client?

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> subject: Adult Health

## 문제

A nurse is caring for a client with severe combined immunodeficiency (SCID) who has been admitted for a bone marrow transplant. Which nursing intervention is the highest priority for this client?

## 보기

1. Implement strict reverse isolation precautions and maintain a sterile environment **✔ 정답**
2. Administer prophylactic antibiotics as prescribed by the physician
3. Monitor vital signs every 4 hours and document any changes
4. Encourage increased fluid intake to prevent dehydration

**정답: 1**

## 해설

Strict reverse isolation is the highest priority to protect the SCID client from life-threatening infections due to their severely compromised immune system. Other interventions like antibiotics and monitoring are supportive but secondary.

## 심화 해설

Correct Answer: 1. Implement strict reverse isolation precautions and maintain a sterile environment

Rationale Deep Dive

For a client with severe combined immunodeficiency (SCID) undergoing a bone marrow transplant, the highest priority nursing intervention is strict reverse isolation and environmental sterility. This decision is rooted in the pathophysiology of the disease and the critical importance of infection prevention during the perioperative and pre-engraftment period.

SCID represents a profound defect in both humoral and cell-mediated immunity. The client has virtually no functional T-cells and B-cells, leaving them defenseless against a wide range of pathogens, including those considered harmless to an immunocompetent person. A bone marrow transplant, while curative, necessitates a conditioning regimen that further ablates any residual bone marrow, rendering the client completely neutropenic and even more vulnerable. During this period of absolute immune incompetence, the acquisition of any infection can be rapidly fatal. The concept of a "sterile environment" is not merely about cleanliness; it is about creating a protective barrier between the client and a microbe-filled world. This aligns directly with the nursing perspective on infection prevention, which emphasizes that a major healthcare-associated outcome, such as infection in an immunocompromised host, is closely tied to the nurse's role in surveillance, assessment, and maintaining the continuity of a protective care environment [1]. The nurse's proactive control of the client's immediate surroundings is the most direct and impactful method to prevent the introduction of exogenous pathogens.

While the other options are important components of care, they do not constitute the highest priority. Administering prophylactic antibiotics (Option 2) is a dependent nursing function that requires a prescription and is a supportive measure, not the primary defense. Antibiotics target bacteria but offer no protection against viral or fungal spores, which are a significant threat in SCID and are best controlled through environmental measures. Monitoring vital signs (Option 3) is a crucial assessment for early detection of infection, but it is a secondary intervention; the priority is to prevent the infection from occurring in the first place. Encouraging fluid intake (Option 4) addresses a general physiological need but does not directly mitigate the immediate, life-threatening risk of overwhelming sepsis in a client with no immune system. The nursing process dictates that for a client with a severely compromised immune system, the planning and implementation of safety-focused interventions to prevent infection take precedence over monitoring for its signs or managing unrelated symptoms.References (research sources)

- [1]Perioperative nursing process-oriented bundled interventions and digital monitoring for the prevention of surgical site infections.Research articleYang Y, Yao S, Pu M, Zhao X, Li Y, Shu Z, Xu L, Kang L, He Z. (2026) · DOI: 10.3389/fmed.2026.1837050

## 임상 시나리오

Protective Environment for SCID & BMTInfection Prevention in the Immunocompromised Host
For a client with Severe Combined Immunodeficiency (SCID) undergoing a bone marrow transplant, the highest priority is implementing strict reverse isolation and maintaining a sterile environment. The client has virtually no functional T-cells or B-cells, and the pre-transplant conditioning regimen induces profound neutropenia (absolute neutrophil count often <100 cells/µL), making any infection rapidly fatal.

Key nursing interventions include placing the client in a private room with HEPA filtration and positive-pressure airflow, requiring all staff and visitors to perform rigorous hand hygiene and wear sterile gowns, gloves, and masks. All items entering the room must be sterile, including linens and dietary trays. Live plants and fresh flowers are prohibited due to fungal and bacterial risks.

CautionDo not confuse reverse isolation (protecting the patient) with standard transmission-based precautions. Aseptic technique is required for all invasive procedures. Monitor closely for subtle signs of infection, as the typical inflammatory response (redness, pus) may be absent in the absence of neutrophils.

## 핵심 개념

- **Severe Combined Immunodeficiency (SCID)** — A primary immunodeficiency disorder characterized by a profound defect in both T-cell and B-cell function, leaving the individual highly susceptible to severe infections.
- **Reverse Isolation** — A protective isolation method used to protect immunocompromised patients from pathogens by placing a barrier between them and the external environment.
- **Bone Marrow Transplant (BMT)** — A curative procedure for SCID involving the infusion of healthy hematopoietic stem cells, preceded by a conditioning regimen that ablates the patient's remaining immune cells.
- **Neutropenia** — An abnormally low count of neutrophils, a type of white blood cell essential for fighting bacterial and fungal infections, often resulting from conditioning regimens before BMT.

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