# A nurse is caring for a client with Addison's disease who presents with severe hypotension, dehydration, and electrolyte imbalances during an acute adrenal crisis. Which nursing intervention should be the priority?

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## 문제

A nurse is caring for a client with Addison's disease who presents with severe hypotension, dehydration, and electrolyte imbalances during an acute adrenal crisis. Which nursing intervention should be the priority?

## 보기

1. Monitor blood glucose levels every 2 hours
2. Administer prescribed IV corticosteroids immediately **✔ 정답**
3. Encourage increased oral fluid intake
4. Position the client in high Fowler's position

**정답: 2**

## 해설

During an adrenal crisis, the immediate priority is to replace the deficient corticosteroids to prevent cardiovascular collapse and death.

An adrenal crisis (Addisonian crisis) in patients with Addison's disease is a life-threatening emergency caused by a severe deficiency of cortisol and aldosterone. This condition can be triggered by stress, infection, trauma, or sudden discontinuation of corticosteroid therapy.

Pathophysiologically, the adrenal cortex fails to produce sufficient amounts of cortisol and aldosterone. Cortisol deficiency leads to severe hypotension, hypoglycemia, and an inability to respond to stress. Aldosterone deficiency causes severe dehydration, hyperkalemia, and hyponatremia. Without immediate intervention, cardiovascular collapse and death can occur within hours.

The priority nursing intervention is the immediate administration of prescribed intravenous corticosteroids. Typically, hydrocortisone or methylprednisolone is used. This intervention directly addresses the underlying pathophysiology by replacing the deficient hormones. Intravenous corticosteroids help stabilize blood pressure, improve cardiac output, restore electrolyte balance, and prevent further deterioration.

Administration must be immediate. Every moment of delay increases the risk of cardiovascular collapse. Intravenous administration is preferred over oral administration because it ensures rapid absorption and immediate therapeutic effect, which is especially important when the patient may have gastrointestinal symptoms that could interfere with oral absorption.

This intervention takes precedence over other supportive measures because it addresses the root cause of the crisis. Once corticosteroid replacement therapy is initiated, other interventions such as fluid resuscitation and electrolyte correction can become more effective.

## 심화 해설

Understanding Addisonian Crisis Pathophysiology

Addison's disease results from primary adrenal insufficiency, where the adrenal cortex fails to produce adequate amounts of critical hormones, primarily cortisol (a glucocorticoid) and aldosterone (a mineralocorticoid) [1]. During an acute adrenal crisis, this deficiency becomes life-threatening. Cortisol is essential for maintaining vascular tone and responsiveness to catecholamines; without it, profound vasodilation and capillary leak occur, leading to severe hypotension that is often refractory to fluids and vasopressors alone [2][4]. Aldosterone deficiency prevents the kidneys from conserving sodium and water while impairing potassium and hydrogen ion excretion, resulting in profound dehydration, hyponatremia (sodium levels as low as 106 mmol/L), and hyperkalemia (potassium levels such as 5.6 mmol/L) [3]. The combination of fluid volume deficit and loss of vascular tone creates a state of hypovolemic and distributive shock.

Prioritizing the Nursing Intervention

In a client exhibiting the classic triad of an adrenal crisis—severe hypotension, dehydration, and electrolyte imbalances—the immediate priority is to reverse the underlying hormonal deficiency. The cornerstone of crisis management is the rapid administration of parenteral glucocorticoids. Administering prescribed IV corticosteroids immediately directly addresses the pathophysiological root cause by restoring cortisol activity, which rapidly improves vascular tone and blood pressure. Case evidence demonstrates that hypotension unresponsive to aggressive fluid resuscitation and high-dose vasopressors resolves quickly after an IV corticosteroid bolus, such as hydrocortisone 100 mg or methylprednisolone 75 mg [2][4]. Delaying this intervention to perform other assessments or interventions can lead to cardiovascular collapse and cardiac arrest, as the shock state is fundamentally driven by the hormone deficiency [4].

Analysis of Other Options

- Option 1: Monitor blood glucose levels every 2 hours. While hypoglycemia is a recognized clinical feature of adrenal insufficiency due to cortisol's role in gluconeogenesis, monitoring is a secondary assessment [2][3]. In the acute phase with life-threatening shock, the priority is treatment, not ongoing monitoring of a single parameter. Blood glucose management will follow initial stabilization.

- Option 3: Encourage increased oral fluid intake. This intervention is contraindicated in an acute adrenal crisis. The client presents with severe dehydration and hypotension, indicating a critical need for immediate intravascular volume repletion via the IV route. Oral intake is insufficient and potentially dangerous if the client has an altered level of consciousness or nausea, a common precipitating symptom [1].

- Option 4: Position the client in high Fowler's position. Positioning a client with severe hypotension in high Fowler's position would worsen hemodynamic instability by reducing venous return to the heart. The appropriate initial position for a hypotensive crisis is supine with legs elevated to promote cerebral perfusion, though positioning is a supportive measure that does not take precedence over the definitive pharmacological treatment.

Clinical Reasoning for the NCLEX-RN

This question tests the nursing principle of prioritization using a physiological crisis framework. The client’s presentation reflects a state of decompensated shock directly caused by a lack of cortisol. The NCLEX-RN expects the nurse to recognize that for a client in an Addisonian crisis, the definitive, life-saving intervention is the immediate administration of IV corticosteroids. All other interventions, including fluid resuscitation (which is typically initiated concurrently), are supportive and secondary to replacing the deficient hormone that is the primary driver of the refractory shock state [2][3][4].References (research sources)

- [1]Addisonian Crisis in a 39-Year-Old Woman With Primary Adrenal Insufficiency.Research articleItteera MR, Gutierrez M, Patel KH. (2026) · DOI: 10.7759/cureus.103607

- [2]Adrenal Crisis: From Perioperative Clinic to Diagnosis.Research articleGültekin A, Öner KB, Yıldırım İ, Arar C, Gürkan S. (2025) · DOI: 10.7759/cureus.88971

- [3]Think Addison's Disease: Disseminated Tuberculosis Presenting With Adrenal Crisis in a Young Male Patient.Research articleMohamed H, Attia AM, John HT, Owies A, Varrier M. (2025) · DOI: 10.7759/cureus.94091

- [4]Acute Adrenal Crisis Following Etomidate Administration in a Patient With Preexisting Adrenal Insufficiency.Research articleMathur R, Boyadzhyan A, Mora A, Afaq S. (2025) · DOI: 10.7759/cureus.88003

## 임상 시나리오

Managing Acute Adrenal CrisisPrioritizing IV Corticosteroid Administration
In Addisonian crisis, the immediate priority is to administer prescribed IV corticosteroids (e.g., hydrocortisone 100 mg IV bolus). This directly reverses the life-threatening cortisol deficiency causing refractory hypotension and shock.

Cortisol is essential for vascular tone. Without it, profound vasodilation occurs, leading to hypotension unresponsive to fluids alone. Corticosteroids must be given before or concurrently with aggressive IV fluid resuscitation using 0.9% normal saline.

CautionNever delay corticosteroid administration for diagnostic tests in suspected crisis. Do not give oral fluids to a hypotensive client with altered consciousness. Monitor for hyperkalemia and hypoglycemia after initial stabilization.

## 핵심 개념

- **Addisonian Crisis** — Acute, life-threatening exacerbation of Addison's disease characterized by severe hypotension, dehydration, and electrolyte imbalances due to cortisol and aldosterone deficiency.
- **Cortisol** — A glucocorticoid hormone essential for maintaining vascular tone and responsiveness to catecholamines; deficiency leads to profound vasodilation and refractory shock.
- **Aldosterone** — A mineralocorticoid hormone that promotes sodium and water retention and potassium excretion; deficiency causes hyponatremia, hyperkalemia, and severe dehydration.
- **IV Corticosteroids** — Parenteral glucocorticoids (e.g., hydrocortisone) that rapidly restore cortisol activity, reversing the underlying hormonal deficiency in adrenal crisis.

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