# A 45-year-old patient is admitted to the emergency department with signs of distributive shock following a severe allergic reaction. The patient's blood pressure is 70/40 mmHg, heart rate is 120 bpm, and oxygen saturation is 88% on room air. Which nursing intervention should be the highest priority?

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## 문제

A 45-year-old patient is admitted to the emergency department with signs of distributive shock following a severe allergic reaction. The patient's blood pressure is 70/40 mmHg, heart rate is 120 bpm, and oxygen saturation is 88% on room air. Which nursing intervention should be the highest priority?

## 보기

1. Administer high-flow oxygen via non-rebreather mask at 15 L/min
2. Establish two large-bore IV lines and begin rapid fluid resuscitation
3. Prepare for immediate administration of epinephrine 1:1000 intramuscularly **✔ 정답**
4. Position the patient in Trendelenburg position to improve venous return

**정답: 3**

## 해설

In anaphylactic shock, epinephrine is the first-line treatment and must be administered immediately to counteract the massive histamine release and restore cardiovascular stability.

Anaphylactic shock is a severe, life-threatening allergic reaction that requires immediate recognition and treatment. This type of distributive shock occurs when massive histamine release causes widespread vasodilation, increased capillary permeability, and potential airway compromise.

Pathophysiologically, IgE-mediated mast cell degranulation occurs, releasing inflammatory mediators that cause systemic vasodilation, increased vascular permeability, and smooth muscle contraction. The patient's blood pressure of 70/40 mmHg, heart rate of 120 beats/min, and oxygen saturation of 88% indicate severe circulatory failure and respiratory distress.

Epinephrine is the core drug for treating anaphylaxis, directly counteracting the pathophysiological processes occurring during the reaction. As an alpha- and beta-adrenergic agonist, epinephrine restores blood pressure through vasoconstriction (alpha effect) and relieves airway constriction through bronchodilation (beta-2 effect). It also stabilizes mast cells and basophils, preventing further mediator release.

The recommended dose is intramuscular epinephrine 1:1000 (1 mg/mL), typically 0.3-0.5 mg for adults administered into the anterolateral thigh. Intramuscular administration is preferred over subcutaneous injection because it provides faster and more reliable absorption, especially in shock states where peripheral circulation may be compromised.

Oxygen therapy, intravenous access, and positioning are important supportive measures but do not address the underlying pathophysiology of anaphylaxis. Without epinephrine, the shock state worsens due to histamine-mediated vasodilation and increased capillary permeability. Time is critical in anaphylaxis, and delayed epinephrine administration is associated with increased morbidity and mortality.

## 심화 해설

Clinical Priority in Distributive Shock from Anaphylaxis

The scenario describes a patient with distributive shock secondary to a severe allergic reaction (anaphylaxis), presenting with profound hypotension (70/40 mmHg), compensatory tachycardia (120 bpm), and significant hypoxemia (88% on room air). In the hierarchy of interventions for anaphylactic shock, the highest priority is the immediate administration of intramuscular epinephrine. This is not merely a pharmacological option but the definitive first-line treatment that directly counteracts the underlying pathophysiology of mast cell and basophil degranulation [1].

The rationale is rooted in the mechanism of distributive shock. The release of massive amounts of histamine and other vasoactive mediators causes severe peripheral vasodilation and increased capillary permeability, leading to a relative hypovolemia and maldistribution of blood flow. Epinephrine, through its alpha-1 adrenergic receptor agonist effects, directly reverses this pathological vasodilation, restoring systemic vascular resistance and blood pressure. Its beta-1 effects increase cardiac output, while its beta-2 effects provide critical bronchodilation and further stabilize mast cell membranes by reducing intracellular cyclic AMP, halting further release of inflammatory mediators [1]. The protocol emphasizes that early recognition and immediate epinephrine administration are paramount to prevent progression to cardiovascular collapse [1].

While the other interventions are essential components of care, they are secondary in priority to epinephrine. Administering high-flow oxygen addresses the hypoxemia but does not treat the root cause of the airway edema and shock. Establishing IV access and initiating fluid resuscitation is a critical adjunct to replace intravascular volume lost to third-spacing, but crystalloid infusion alone cannot reverse the profound vasoplegia. The Trendelenburg position is a temporary, non-pharmacological maneuver with limited and transient efficacy in shock and is not a definitive intervention. Delaying epinephrine to perform these other tasks first allows the anaphylactic cascade to progress unchecked, increasing the risk of airway obstruction and refractory shock [1].References (research sources)

- [1]International Pain and Spine Intervention Society emergency protocols: Allergic and anaphylactic reactions.Research articleSmith CC, Meral RM, Wasserman RA. (2026) · DOI: 10.1016/j.inpm.2026.100796

## 임상 시나리오

Anaphylactic Shock: Nursing PriorityEpinephrine First, Always
In distributive shock from anaphylaxis, the highest priority is IM epinephrine (1:1000 concentration) into the anterolateral thigh. It is the only intervention that directly halts mast cell degranulation and reverses vasodilation.

Epinephrine's alpha-1 effects restore vascular tone and blood pressure, while beta-2 effects provide bronchodilation and stabilize mast cells. Supportive measures like oxygen and IV fluids are secondary and should be initiated after or concurrently with epinephrine.

CautionDo not delay epinephrine to establish IV access or administer other drugs. In anaphylaxis, even a brief delay can result in cardiovascular collapse. The Trendelenburg position is not recommended and may compromise breathing.

## 핵심 개념

- **Distributive Shock** — A type of shock characterized by profound vasodilation and maldistribution of blood flow, as seen in anaphylaxis, sepsis, or neurogenic injury.
- **Epinephrine 1:1000 IM** — The first-line pharmacological agent for anaphylaxis, administered intramuscularly into the anterolateral thigh to reverse vasodilation, bronchoconstriction, and mediator release.
- **Anaphylaxis** — A severe, life-threatening systemic hypersensitivity reaction involving mast cell degranulation, leading to airway edema, bronchospasm, and cardiovascular collapse.

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