# A nurse is caring for a patient with septic shock who has a pulmonary artery catheter in place. Which assessment finding would be most indicative of worsening cardiac function? > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=540275 > language: ko > subject: Adult Health ## 문제 A nurse is caring for a patient with septic shock who has a pulmonary artery catheter in place. Which assessment finding would be most indicative of worsening cardiac function? ## 보기 1. Systemic vascular resistance of 1,000 dynes/sec/cm⁵ 2. Cardiac output of 4.5 L/min 3. Central venous pressure of 4 mm Hg 4. Pulmonary artery wedge pressure of 22 mm Hg **✔ 정답** **정답: 4** ## 해설 PAWP of 22 mmHg indicates severely elevated left atrial pressure and pulmonary congestion, characteristic of worsening cardiogenic shock. Other values are within normal or less concerning ranges. ## 심화 해설 Understanding the Question This question asks you to identify the assessment finding that most directly indicates worsening cardiac function in a patient with septic shock who has a pulmonary artery (PA) catheter. To answer this, you must understand the hemodynamic parameters measured by a PA catheter and how they reflect the pathophysiology of sepsis-induced cardiomyopathy (SICM). Analyzing the Hemodynamic Profile in Septic Shock Septic shock is a form of distributive shock characterized by profound vasodilation and, in many cases, myocardial depression. The PA catheter provides direct and indirect measurements of cardiac performance and vascular tone. The hallmark of SICM, as described in the provided literature, is a global, reversible myocardial depression leading to biventricular dilatation and a reduced ejection fraction [3, 4]. Let's analyze each option in the context of this pathophysiology. - **Systemic vascular resistance (SVR) of 1,000 dynes/sec/cm⁵** SVR reflects the afterload, or the resistance the left ventricle must overcome to eject blood. In septic shock, a defining feature is massive vasodilation due to inflammatory mediators, leading to a pathologically *low* SVR. A normal SVR is roughly 800-1200 dynes/sec/cm⁵. A value of 1,000 is within normal limits. While a "normal" SVR in a septic patient who should have low SVR might suggest vasopressor effect or a different phase of shock, it is not a direct indicator of cardiac muscle function. It reflects vascular tone, not myocardial contractility. - **Cardiac output (CO) of 4.5 L/min** Cardiac output is the volume of blood pumped by the heart per minute. A normal resting CO is approximately 4-8 L/min. In the hyperdynamic phase of septic shock, CO is typically elevated as a compensatory response to low SVR, despite underlying myocardial depression [3]. A CO of 4.5 L/min is low-normal. While a falling CO in a previously hyperdynamic patient is concerning, a single value in the normal range does not definitively isolate the problem to worsening *cardiac* function; it could be influenced by inadequate preload or other factors. - **Central venous pressure (CVP) of 4 mm Hg** CVP approximates the right atrial pressure and reflects right ventricular preload. A normal CVP is 2-8 mm Hg. A CVP of 4 mm Hg is normal. While a very high CVP could indicate right ventricular failure or fluid overload, a normal value does not signal worsening cardiac function. It is more useful for guiding fluid resuscitation. - **Pulmonary artery wedge pressure (PAWP) of 22 mm Hg** PAWP, also known as pulmonary capillary wedge pressure (PCWP), is a critical measurement. By inflating a balloon at the catheter tip, the catheter "wedges" in a small pulmonary artery branch, creating a static fluid column that reflects the pressure in the left atrium and, during diastole, the left ventricular end-diastolic pressure (LVEDP). This is a direct assessment of left ventricular preload. A normal PAWP is 8-12 mm Hg. A PAWP of 22 mm Hg is significantly elevated. In the context of septic shock, this is a critical finding. The literature explains that SICM causes global hypokinesia and increased left ventricular end-diastolic volume [1, 3]. As the failing left ventricle becomes less compliant and cannot effectively pump blood forward, pressure backs up into the left atrium and pulmonary vasculature, causing a sharp rise in PAWP. This elevated pressure can lead to pulmonary edema. Therefore, a high PAWP is a direct hemodynamic sign of left ventricular dysfunction and worsening pump failure. Connecting the Finding to the Pathophysiology The provided evidence clearly establishes that myocardial depression is a core component of septic shock. The study by Parrillo et al. [4] demonstrated that a circulating myocardial depressant substance in patients with septic shock directly impairs cardiac myocyte contractility, leading to a reduced ejection fraction and ventricular dilatation. Court et al. [3] further clarify that this dysfunction manifests as biventricular dilatation despite a fluid-resuscitated hyperdynamic state. The dilated, failing ventricle has an increased end-diastolic volume and pressure, which is precisely what an elevated PAWP measures. An SVR of 1,000 dynes/sec/cm⁵ and a CVP of 4 mm Hg are normal values that do not indicate a problem, while a CO of 4.5 L/min is a non-specific finding. The markedly elevated PAWP of 22 mm Hg is the finding that directly corresponds to the pathophysiological hallmark of SICM: a failing left ventricle with rising filling pressures [1, 3].References (research sources) - [3]Clinical review: Myocardial depression in sepsis and septic shock.Research articleOlivier Court, Aseem Kumar, Joseph E. Parrillo, Anand Kumar (2002) · DOI: 10.1186/cc1822 - [4]A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.Research articleJoseph E. Parrillo, Cynthia Burch, James H. Shelhamer, Margaret M. Parker, Charles Natanson, R. Schuette (1985) · DOI: 10.1172/jci112135 ## 임상 시나리오 Hemodynamic Monitoring in Septic ShockInterpreting PA Catheter Data for Cardiac Dysfunction In septic shock, worsening cardiac function is best identified by a rising pulmonary artery wedge pressure (PAWP). A PAWP of 22 mm Hg indicates elevated left ventricular filling pressure, a hallmark of pump failure. Do not rely solely on cardiac output or SVR. Sepsis-induced cardiomyopathy often presents with a normal or high cardiac output initially, and SVR primarily reflects vascular tone, not contractility. CautionA normal CVP does not rule out left ventricular failure. Always correlate PAWP with other clinical signs of hypoperfusion to differentiate fluid responsiveness from cardiogenic compromise. ## 핵심 개념 - **Pulmonary Artery Wedge Pressure (PAWP)** — A measurement of left ventricular end-diastolic pressure used to assess left heart filling; elevated values indicate increased preload and potential left ventricular failure. - **Sepsis-Induced Cardiomyopathy (SICM)** — A reversible myocardial depression in sepsis characterized by biventricular dilatation and reduced ejection fraction, often masked by a normal or high cardiac output. - **Systemic Vascular Resistance (SVR)** — The resistance the left ventricle must overcome to eject blood; it is typically low in septic shock due to vasodilation. - **Central Venous Pressure (CVP)** — A measure of right ventricular preload and right heart function, not a direct indicator of left ventricular performance. ## 같은 주제 문제 - [A nurse is caring for a patient with cardiogenic shock who has a pulmonary artery catheter…](https://mymerci.kr/pages/nclex_q.php?qn_id=540274) - [A nurse is caring for a patient with acute decompensated heart failure who has a pulmonary…](https://mymerci.kr/pages/nclex_q.php?qn_id=540276) - [A nurse is caring for a patient in cardiogenic shock who has an intra-aortic balloon pump …](https://mymerci.kr/pages/nclex_q.php?qn_id=540277) - [A nurse is caring for a patient in cardiogenic shock who has an intra-aortic balloon pump.…](https://mymerci.kr/pages/nclex_q.php?qn_id=540278) - [A patient in cardiogenic shock has a pulmonary artery catheter inserted for hemodynamic mo…](https://mymerci.kr/pages/nclex_q.php?qn_id=540279) - [A nurse is caring for a patient with septic shock who has a pulmonary artery catheter in p…](https://mymerci.kr/pages/nclex_q.php?qn_id=540280) --- More free questions: [기출문제](https://mymerci.kr/) _학습 참고용입니다. 실제 임상은 최신 지침과 소속 기관 프로토콜을 따르세요._