# 服用capivasertib的個案出現劇烈口渴、頻尿、噁心、腹痛、深而快的呼吸，以及血清酮體陽性。哪項措施是優先事項？

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=523000&lang=zh-tw  
> language: zh-TW  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## 題目

服用capivasertib的個案出現劇烈口渴、頻尿、噁心、腹痛、深而快的呼吸，以及血清酮體陽性。哪項措施是優先事項？

## 選項

1. 給予下一劑capivasertib時搭配含糖飲料。
2. 等待下次預定的腫瘤科門診。
3. 將這些發現視為預期的輕微腹瀉進行治療。
4. 立即停用capivasertib，並尋求緊急評估和治療，以處理疑似糖尿病酮酸中毒。 **✔ 正確答案**

**正確答案: 4**

## 解析

Capivasertib可能導致嚴重高血糖、糖尿病酮酸中毒和致命的代謝併發症。疑似酮酸中毒需要立即停藥並進行緊急醫療處置。

## 深入解析

快速解答
將高血糖症狀加上酮體視為疑似酮酸中毒進行治療。

為何這是正確的
多尿、多渴、腹部症狀、深呼吸和酮體構成代謝急症模式。常規延遲或額外的藥物暴露會使失代償惡化。

簡單類比或心像
建立藥物安全鏈：識別變化的線索，將其與標示的毒性或交互作用連結，中斷可預防的暴露，穩定個案，並驗證可測量的反應。

記憶點
藥物、趨勢、緊急線索、保護性措施和再評估終點。

NCLEX決策規則
選擇能預防最即時藥物相關危害的措施，同時保留指示的治療和所需的監測。

為何其他選項是錯誤的
繼續可疑暴露、將標示的危險線索正常化或延遲升級的選項會使個案處於危險之中。參考資料
1DailyMed: TRUQAP (capivasertib)嚴重高血糖和酮酸中毒的識別、立即中斷、血糖監測、腹瀉和皮膚毒性

## 臨床情境

腫瘤藥物安全審查
驗證適應症、當前評估、實驗室和氧氣趨勢、交互作用、緊急毒性線索、授權行動和可測量的後續追蹤。

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