# A client receiving belzutifan develops worsening fatigue and dyspnea. Review the record and select the priority action.

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=en  
> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

A client receiving belzutifan develops worsening fatigue and dyspnea. Review the record and select the priority action.

History

Vitals

Labs

Orders

Notes

Renal-cell carcinoma treated with belzutifan; baseline hemoglobin 11.8 g/dL and oxygen saturation 97%

(데이터 없음)

(데이터 없음)

Supplemental oxygen and urgent oncology evaluation are available

(데이터 없음)

1

Administer the next dose and repeat the tests at the next routine visit.

✕

2

Hold belzutifan, provide oxygen and urgent clinical evaluation, and notify the oncology prescriber about severe anemia and hypoxia.

✕

3

Increase the dose because hypoxia indicates tumor response.

✕

4

Treat fatigue with caffeine and ignore the oxygen saturation.

✕

## Explanation

Belzutifan can cause severe anemia and hypoxia. Hemoglobin 7.6 g/dL with oxygen saturation 86% at rest requires withholding therapy and urgent assessment, oxygen support, and severity-directed oncology management.

## In-depth explanation

Quick answer
Escalate severe anemia plus resting hypoxia during belzutifan therapy.

Why this is correct
HIF-2 alpha inhibition can reduce erythropoietin signaling and contribute to anemia. The label also requires baseline and serial oxygen monitoring and interruption for clinically important resting hypoxia.

Easy analogy or mental picture
Build a medication-safety chain: identify the changing cue, connect it to the labeled toxicity or interaction, interrupt preventable exposure, stabilize the client, and verify a measurable response.

Memory hook
Drug, trend, urgent cue, protective action, and reassessment endpoint.

NCLEX decision rule
Choose the action that prevents the most immediate medication-related harm while preserving indicated treatment and required monitoring.

Why the other choices are wrong
Options that continue a suspect exposure, normalize a labeled danger cue, or delay escalation leave the client at risk.References
1DailyMed: WELIREG (belzutifan)Anemia and hypoxia monitoring, dose interruption thresholds, urgent oxygen support, and life-threatening toxicity response

## Clinical scenario

Oncology medication-safety review
Verify indication, current assessment, laboratory and oxygen trends, interactions, urgent toxicity cues, authorized action, and measurable follow-up.

## Related questions

- [A client is admitted to the emergency department after ingesting an unknown amount of acet…](https://mymerci.kr/pages/nclex_q.php?qn_id=362720&lang=en)
- [A client with chronic heart failure is prescribed metoprolol 25 mg orally twice daily. Bef…](https://mymerci.kr/pages/nclex_q.php?qn_id=362756&lang=en)
- [A 28-year-old client with type 1 diabetes receives regular insulin 6 units and NPH insulin…](https://mymerci.kr/pages/nclex_q.php?qn_id=362792&lang=en)
- [A client receives IV vancomycin 1 g every 12 hours for MRSA bacteremia. Before the next do…](https://mymerci.kr/pages/nclex_q.php?qn_id=362833&lang=en)
- [A client with bipolar disorder has been taking lithium carbonate 600 mg orally three times…](https://mymerci.kr/pages/nclex_q.php?qn_id=362894&lang=en)
- [A nurse is monitoring a client receiving a continuous IV heparin infusion for pulmonary em…](https://mymerci.kr/pages/nclex_q.php?qn_id=363988&lang=en)
- [A nurse is preparing to initiate a weight-based continuous IV unfractionated heparin infus…](https://mymerci.kr/pages/nclex_q.php?qn_id=364107&lang=en)
- [A nurse is providing discharge teaching to a 65-year-old client newly prescribed warfarin …](https://mymerci.kr/pages/nclex_q.php?qn_id=364872&lang=en)

## Read in another language

- [en](https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=en)
- [ko](https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=ko)
- [ja](https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=ja)
- [zh-TW](https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=zh-tw)
- [vi](https://mymerci.kr/pages/nclex_q.php?qn_id=522995&lang=vi)

---

More free questions: [NCLEX-RN Practice](https://mymerci.kr/pages/nclex_bank.php?lang=en)

_For study reference only. Always follow current clinical guidelines and your institution’s protocols._