# 服用 mavacamten 治療阻塞性肥厚性心肌病的個案報告出現新的呼吸困難和腳踝水腫。檢閱病歷並選擇優先行動。 > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=zh-tw > language: zh-TW > subject: Adverse Effects/Contraindications/Interactions > category: PPT ## 題目 服用 mavacamten 治療阻塞性肥厚性心肌病的個案報告出現新的呼吸困難和腳踝水腫。檢閱病歷並選擇優先行動。 History Vitals Labs Orders Notes 阻塞性肥厚性心肌病；mavacamten 治療並定期進行心臟超音波監測 (데이터 없음) (데이터 없음) (데이터 없음) (데이터 없음) 1 給予下一劑藥物並在 6 個月後重複心臟超音波檢查。 ✕ 2 暫停 mavacamten，立即通知處方醫師，並安排評估收縮功能障礙和藥物交互作用。 ✕ 3 將劑量加倍，因為呼吸困難惡化證明阻塞治療不足。 ✕ 4 在未進行心臟超音波檢查的情況下，停止所有心臟藥物。 ✕ ## 解析 新出現的心臟衰竭症狀，且左心室射出分率 (LVEF) 低於 50%，需要中斷 mavacamten 並立即評估。新添加的 CYP3A4 抑制劑會增加藥物暴露並惡化收縮功能障礙。 ## 深入解析 快速解答 將 新的呼吸困難、LVEF 47% 和 CYP 抑制劑與 mavacamten 相關的收縮功能障礙連結起來。 為什麼這是正確的 Mavacamten 會降低心肌肌球蛋白活性，並可能導致收縮功能障礙引起的心臟衰竭。藥物標示的監測途徑使用症狀、心臟超音波檢查和交互作用審查來決定中斷和安全恢復用藥。 簡單類比或心像 建立藥物安全鏈：識別新的線索，將其與藥物機制或標示限制連結，停止可預防的暴露，穩定個案，並驗證可測量的反應。 記憶點 藥物、緊急線索、保護性行動和重新評估終點。 NCLEX 決策規則 選擇能預防最直接藥物相關危害的行動，同時保留指示治療和必要的監測。 為什麼其他選項是錯誤的 繼續可疑暴露、將標示的危險線索正常化、替代未經授權的劑量或延遲升級的選項會使個案處於危險之中。References 1DailyMed: CAMZYOS (mavacamten)Boxed heart-failure warning, echocardiographic LVEF surveillance, treatment interruption, and interacting-drug safety ## 臨床情境 藥物安全審查 驗證適應症、當前評估、劑量和途徑、器官功能、交互作用、緊急毒性線索、授權行動和可測量的追蹤。 ## 相同主題題目 - [A client is admitted to the emergency department after ingesting an unknown amount of acet…](https://mymerci.kr/pages/nclex_q.php?qn_id=362720&lang=zh-tw) - [A client with chronic heart failure is prescribed metoprolol 25 mg orally twice daily. Bef…](https://mymerci.kr/pages/nclex_q.php?qn_id=362756&lang=zh-tw) - [A 28-year-old client with type 1 diabetes receives regular insulin 6 units and NPH insulin…](https://mymerci.kr/pages/nclex_q.php?qn_id=362792&lang=zh-tw) - [A client receives IV vancomycin 1 g every 12 hours for MRSA bacteremia. Before the next do…](https://mymerci.kr/pages/nclex_q.php?qn_id=362833&lang=zh-tw) - [A client with bipolar disorder has been taking lithium carbonate 600 mg orally three times…](https://mymerci.kr/pages/nclex_q.php?qn_id=362894&lang=zh-tw) - [A nurse is monitoring a client receiving a continuous IV heparin infusion for pulmonary em…](https://mymerci.kr/pages/nclex_q.php?qn_id=363988&lang=zh-tw) - [A nurse is preparing to initiate a weight-based continuous IV unfractionated heparin infus…](https://mymerci.kr/pages/nclex_q.php?qn_id=364107&lang=zh-tw) - [A nurse is providing discharge teaching to a 65-year-old client newly prescribed warfarin …](https://mymerci.kr/pages/nclex_q.php?qn_id=364872&lang=zh-tw) ## 以其他語言閱讀 - [en](https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=en) - [ko](https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=ko) - [ja](https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=ja) - [zh-TW](https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=zh-tw) - [vi](https://mymerci.kr/pages/nclex_q.php?qn_id=522928&lang=vi) --- More free questions: [NCLEX-RN 題庫](https://mymerci.kr/pages/nclex_bank.php?lang=zh-tw) _僅供學習參考。實際臨床請遵循最新指引與所屬機構規範。_