# Which history should cause the nurse to question an isavuconazonium prescription?

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=522887&lang=en  
> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

Which history should cause the nurse to question an isavuconazonium prescription?

## Option

1. Seasonal allergic rhinitis
2. Corrected myopia
3. Remote appendectomy
4. Familial short-QT syndrome **✔ Correct answer**

**Correct answer: 4**

## Explanation

Isavuconazole shortens the QT interval and is contraindicated in familial short-QT syndrome. It also has important strong CYP3A4 interaction restrictions.

## In-depth explanation

Quick answer
Unlike many azoles, isavuconazole can shorten QT.

Why this is correct
The direction of the QT effect is clinically important and makes familial short-QT syndrome a specific contraindication.

Easy analogy or mental picture
Build a medication-safety chain: identify the new cue, connect it to the drug mechanism or labeled limitation, stop preventable exposure, stabilize the client, and verify a measurable response.

Memory hook
Drug, urgent cue, protective action, and reassessment endpoint.

NCLEX decision rule
Choose the action that prevents the most immediate medication-related harm while preserving indicated treatment and required monitoring.

Why the other choices are wrong
Options that continue a suspect exposure, normalize a labeled danger cue, substitute an unauthorized dose, or delay escalation leave the client at risk.References
1DailyMed: CRESEMBA (isavuconazonium sulfate)QT shortening and familial short-QT contraindication

## Clinical scenario

Medication-safety review
Verify indication, current assessment, dose and route, organ function, interactions, urgent toxicity cues, authorized action, and measurable follow-up.

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