# A client receiving tezepelumab for severe asthma develops acute wheezing, accessory-muscle use, and difficulty speaking. Which action is best?

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=522603&lang=en  
> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

A client receiving tezepelumab for severe asthma develops acute wheezing, accessory-muscle use, and difficulty speaking. Which action is best?

## Option

1. Use the scheduled tezepelumab injection as the only rescue treatment and wait for it to reverse the bronchospasm.
2. Stop inhaled and systemic corticosteroids immediately because biologic therapy now replaces both.
3. Delay respiratory assessment and wait for the next scheduled biologic appointment before using rescue therapy.
4. Activate the prescribed acute-asthma rescue plan and urgent assessment; tezepelumab is not a rescue drug. **✔ Correct answer**

**Correct answer: 4**

## Explanation

Tezepelumab is maintenance treatment and does not treat acute bronchospasm or status asthmaticus. Acute respiratory distress requires rescue therapy and urgent assessment.

## In-depth explanation

Quick answer
Do not substitute maintenance biologic therapy for acute asthma rescue.

Why this is correct
Corticosteroids also should not be stopped abruptly when tezepelumab begins; any reduction is gradual and supervised.

Easy analogy or mental picture
Use a closed medication-safety loop: identify the immune or cytotoxic exposure, connect the new findings, interrupt further harm, stabilize the client, and verify the response over time.

Memory hook
Exposure, immune effect, organ toxicity, infection risk, immediate action, and serial reassessment.

NCLEX decision rule
Choose the action that reduces the most immediate medication-related risk while preserving diagnostic evaluation and authorized treatment.

Why the other choices are wrong
Options that continue the exposure, treat only one symptom, or delay reassessment leave the toxic or infectious process active.References
1DailyMed: TEZSPIRE (tezepelumab)Maintenance treatment, no role in acute bronchospasm, gradual corticosteroid reduction, helminth infection, and live-vaccine avoidance

## Clinical scenario

Oncology, transplant, and biologic safety review
Verify the indication, immune status, infection screen, interacting medicines, current organ findings, authorized action, and measurable follow-up.

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