# 移植受贈者因移植後巨細胞病毒感染而開始使用maribavir。請根據每個發現所支持的用藥安全決策進行分類。 > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=zh-tw > language: zh-TW > subject: Adverse Effects/Contraindications/Interactions > category: PPT ## 題目 移植受贈者因移植後巨細胞病毒感染而開始使用maribavir。請根據每個發現所支持的用藥安全決策進行分類。 | | 避免，因為抗病毒活性或maribavir療效可能會下降 | 監測或調整交互作用藥物 | 加強CMV病毒學追蹤 | | --- | --- | --- | --- | | valganciclovir仍按計畫與maribavir同時使用 | | | | | rifampin是新開立的處方 | | | | | 病人服用digoxin | | | | | 病人服用cyclosporine | | | | | 治療期間CMV DNA升高 | | | | | 治療結束 5 週後CMV症狀復發 | | | | ## 解析 maribavir 可能會拮抗valganciclovir或ganciclovir；rifampin或聖約翰草可能會降低maribavir的療效；digoxin和鈣調磷酸酶抑制劑的暴露量可能會增加；必須追蹤CMV DNA以監測治療失敗或復發。 ## 深入解析 快速解答 區分抗病毒拮抗作用、藥物動力學交互作用和病毒學監測。 為什麼這是正確的 Maribavir 具有臨床上重要的雙向交互作用，且治療期間或之後可能發生與抗藥性相關的治療失敗。藥物協調和CMV DNA監測都至關重要。 簡單類比或心像 使用閉環式用藥安全流程：識別免疫或細胞毒性暴露、連結新發現、中斷進一步傷害、穩定病人，並隨時間驗證反應。 記憶點 暴露、免疫作用、器官毒性、感染風險、立即行動和系列性再評估。 NCLEX決策規則 選擇能降低最直接的藥物相關風險，同時保留診斷評估和授權治療的行動。 為什麼其他選項是錯誤的 繼續暴露、僅治療單一症狀或延遲再評估的選項會使毒性或感染過程持續活躍。References 1DailyMed: LIVTENCITY (maribavir)與ganciclovir或valganciclovir的拮抗作用、CYP3A誘導劑效應、監測交互作用和CMV DNA追蹤 ## 臨床情境 腫瘤學、移植和生物製劑安全審查 核實適應症、免疫狀態、感染篩查、交互作用藥物、當前器官發現、授權行動和可測量的追蹤。 ## 相同主題題目 - [A client is admitted to the emergency department after ingesting an unknown amount of acet…](https://mymerci.kr/pages/nclex_q.php?qn_id=362720&lang=zh-tw) - [A client with chronic heart failure is prescribed metoprolol 25 mg orally twice daily. Bef…](https://mymerci.kr/pages/nclex_q.php?qn_id=362756&lang=zh-tw) - [A 28-year-old client with type 1 diabetes receives regular insulin 6 units and NPH insulin…](https://mymerci.kr/pages/nclex_q.php?qn_id=362792&lang=zh-tw) - [A client receives IV vancomycin 1 g every 12 hours for MRSA bacteremia. Before the next do…](https://mymerci.kr/pages/nclex_q.php?qn_id=362833&lang=zh-tw) - [A client with bipolar disorder has been taking lithium carbonate 600 mg orally three times…](https://mymerci.kr/pages/nclex_q.php?qn_id=362894&lang=zh-tw) - [A nurse is monitoring a client receiving a continuous IV heparin infusion for pulmonary em…](https://mymerci.kr/pages/nclex_q.php?qn_id=363988&lang=zh-tw) - [A nurse is preparing to initiate a weight-based continuous IV unfractionated heparin infus…](https://mymerci.kr/pages/nclex_q.php?qn_id=364107&lang=zh-tw) - [A nurse is providing discharge teaching to a 65-year-old client newly prescribed warfarin …](https://mymerci.kr/pages/nclex_q.php?qn_id=364872&lang=zh-tw) ## 以其他語言閱讀 - [en](https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=en) - [ko](https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=ko) - [ja](https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=ja) - [zh-TW](https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=zh-tw) - [vi](https://mymerci.kr/pages/nclex_q.php?qn_id=522598&lang=vi) --- More free questions: [NCLEX-RN 題庫](https://mymerci.kr/pages/nclex_bank.php?lang=zh-tw) _僅供學習參考。實際臨床請遵循最新指引與所屬機構規範。_