# 完成正在接受 cyclosporine 和 letermovir 的成人腎臟移植受者的藥物協調。

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> url: https://mymerci.kr/pages/nclex_q.php?qn_id=522597&lang=zh-tw  
> language: zh-TW  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## 題目

完成正在接受 cyclosporine 和 letermovir 的成人腎臟移植受者的藥物協調。

與 cyclosporine 併用時，成人 letermovir 劑量為每天一次 ::선택::120 mg240 mg480 mg960 mg。護理師應將 ::선택::acetaminophenamoxicillinsimvastatincalcium carbonate 識別為此組合的禁忌症，並頻繁監測 ::선택::cyclosporinesodium chloridehemoglobin A1camylase 濃度。

## 解析

當 letermovir 與 cyclosporine 在成人移植受者中共同給藥時，letermovir 應減至每天一次 240 mg；simvastatin 在此組合中是禁忌的；cyclosporine 濃度需要頻繁監測。

## 深入解析

快速解答
鎖定 cyclosporine-letermovir 劑量和相互作用安全措施。

為何這是正確的
Cyclosporine 會增加 letermovir 的暴露量，且此組合可能大幅增加某些 statin 的濃度。藥物協調必須連結劑量選擇、禁忌症和治療藥物監測。

簡單類比或心像
使用封閉式藥物安全循環：識別免疫或細胞毒性暴露、連結新發現、中斷進一步傷害、穩定病人，並隨時間驗證反應。

記憶點
暴露、免疫效應、器官毒性、感染風險、立即行動和系列重新評估。

NCLEX 決策規則
選擇能降低最直接藥物相關風險的行動，同時保留診斷評估和經授權的治療。

為何其他選項是錯誤的
繼續暴露、僅治療單一症狀或延遲重新評估的選項會使毒性或感染過程持續活躍。References
1DailyMed: PREVYMIS (letermovir)移植後巨細胞病毒預防、cyclosporine 劑量相互作用、statin 禁忌症和藥物濃度監測

## 臨床情境

腫瘤科、移植和生物製劑安全審查
驗證適應症、免疫狀態、感染篩檢、相互作用藥物、當前器官發現、經授權的行動和可測量的後續追蹤。

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