# 針對每個 foscarnet 發現，判斷其藥物安全解釋。可能適用多個欄位。

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=516668&lang=zh-tw  
> language: zh-TW  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## 題目

針對每個 foscarnet 發現，判斷其藥物安全解釋。可能適用多個欄位。

|  | 支持清除率降低 | 支持電解質相關神經學風險 | 支持腎臟保護 |
| --- | --- | --- | --- |
| 肌酸酐從 0.9 增加到 1.6 mg/dL |  |  |  |
| 離子鈣和鎂低於參考範圍 |  |  |  |
| 新出現的口周刺痛和手部抽搐 |  |  |  |
| 輸注前已給予醫囑的水合作用 |  |  |  |
| 班次期間尿量減少 |  |  |  |

## 解析

肌酸酐升高表示清除率下降，低鈣和低鎂會增加癲癇發作風險，水合作用有助於腎臟保護，而新的感覺異常或抽搐需要立即評估。

## 深入解析

快速解答
Foscarnet 的安全性取決於腎功能、水合作用和礦物質平衡。

為什麼這是正確的
腎功能損害是 foscarnet 的主要毒性，劑量必須根據腎功能個別化。離子鈣、鎂、鉀和磷酸鹽的變化可能導致神經肌肉症狀、心律不整或癲癇發作。

簡單類比或心像
腎臟設定了劑量通道，而四個電解質儀表保護著電氣系統。

記憶點
Foscarnet：水合、腎臟劑量調整，並監測鈣、鎂、鉀、磷酸鹽。

NCLEX 決策規則
根據發現是否改變暴露、神經學風險或腎臟保護來分類。

為什麼其他選項是錯誤的
已完成的水合醫囑並不能抵消升高的肌酸酐或有症狀的電解質異常。References
1DailyMed: Foscarnet Sodium InjectionHydration, individualized renal dosing, frequent creatinine and electrolyte monitoring, and seizure risk

## 臨床情境

Foscarnet 監測
追蹤肌酸酐清除率、尿量、水合作用、離子鈣、鎂、鉀、磷酸鹽、心電圖、感覺異常、抽搐和癲癇發作。

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