# For each foscarnet finding, identify the medication-safety interpretation. More than one column may apply.

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> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

For each foscarnet finding, identify the medication-safety interpretation. More than one column may apply.

|  | Supports reduced clearance | Supports electrolyte-related neurologic risk | Supports renal protection |
| --- | --- | --- | --- |
| Creatinine increased from 0.9 to 1.6 mg/dL |  |  |  |
| Ionized calcium and magnesium are below the reference range |  |  |  |
| New perioral tingling and hand twitching |  |  |  |
| Prescribed hydration was administered before the infusion |  |  |  |
| Urine output decreased during the shift |  |  |  |

## Explanation

Rising creatinine indicates declining clearance, low calcium and magnesium increase seizure risk, hydration supports renal protection, and new paresthesia or twitching requires immediate evaluation.

## In-depth explanation

Quick answer
Foscarnet safety depends on kidney function, hydration, and mineral balance.

Why this is correct
Renal impairment is a major foscarnet toxicity, and dose must be individualized to renal function. Ionized calcium, magnesium, potassium, and phosphate shifts can produce neuromuscular symptoms, dysrhythmias, or seizures.

Easy analogy or mental picture
The kidney sets the dose lane while four electrolyte gauges protect the electrical system.

Memory hook
Foscarnet: hydrate, renal-dose, and watch calcium, magnesium, potassium, phosphate.

NCLEX decision rule
Classify the finding by whether it changes exposure, neurologic risk, or renal protection.

Why the other choices are wrong
A completed hydration order does not cancel a rising creatinine or symptomatic electrolyte abnormality.References
1DailyMed: Foscarnet Sodium InjectionHydration, individualized renal dosing, frequent creatinine and electrolyte monitoring, and seizure risk

## Clinical scenario

Foscarnet monitoring
Trend creatinine clearance, urine output, hydration, ionized calcium, magnesium, potassium, phosphate, ECG, paresthesia, twitching, and seizures.

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