# 對於疑似巴氯芬過量中毒的每項發現，請確定其適當的解釋。

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=515769&lang=zh-tw  
> language: zh-TW  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## 題目

對於疑似巴氯芬過量中毒的每項發現，請確定其適當的解釋。

|  | 支持嚴重毒性 | 增加暴露風險 | 令人放心但不足夠 |
| --- | --- | --- | --- |
| 進行性嗜睡，呼吸頻率 7 次/分 |  |  |  |
| 全身性肌張力低下和新發癲癇 |  |  |  |
| eGFR 從 62 降至 24 mL/min/1.73 m2 |  |  |  |
| 體溫 37.1 C |  |  |  |
| 輔助通氣後 SpO2 改善 |  |  |  |

## 解析

嗜睡、肌張力低下、呼吸抑制、癲癇發作和腎功能損害支持嚴重的巴氯芬毒性；突然增加劑量和延遲氣道支持是不安全的。

## 深入解析

快速解答
巴氯芬過量中毒主要是一種氣道和神經學緊急情況。

為什麼這是正確的
說明書描述了進行性嗜睡、昏迷、呼吸抑制、癲癇發作和肌張力低下。巴氯芬主要經腎臟排泄，因此清除率受損會增加風險。

簡單類比或心像
神經系統的調光器卡在太低的位置，而腎臟清除率降低使藥物滯留在體內。

記憶點
巴氯芬過量中毒：肌張力低、呼吸淺、癲癇發作；支持氣道。

NCLEX決策規則
將立即威脅與風險放大因素和令人放心的發現分開歸類。

為什麼其他選項是錯誤的
正常體溫並不能逆轉呼吸抑制，而給予更多巴氯芬會加重暴露。References
1DailyMed: Baclofen Oral Suspension過量中毒發現、氣道支持、呼吸管理和腎臟注意事項

## 臨床情境

巴氯芬毒性
支持氣道和通氣，監測神經學和血流動力學狀態，評估腎功能，並聯繫毒物中心。

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