# 對於每個 memantine 發現，確定適當的解釋。 > source: MyMerci (mymerci.kr) > url: https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=zh-tw > language: zh-TW > subject: Adverse Effects/Contraindications/Interactions > category: PPT ## 題目 對於每個 memantine 發現，確定適當的解釋。 | | 需要澄清劑量 | 適當的指示 | 不會觸發嚴重腎功能限制 | | --- | --- | --- | --- | | CrCl 24 mL/min，醫囑為速效 memantine 10 mg BID | | | | | CrCl 24 mL/min，授權目標為 5 mg BID | | | | | 病人錯過單次劑量，並計畫在不加倍的情況下服用下一次預定劑量 | | | | | 病人錯過數天，並計畫在未經審查的情況下重新開始服用完整目標劑量 | | | | | CrCl 68 mL/min，無肝功能不全 | | | | ## 解析 嚴重腎功能不全將速效劑型的目標劑量限制為 5 mg BID。10 mg BID 的醫囑需要澄清，並且錯過數天可能需要從較低劑量重新開始並重新調整。 ## 深入解析 快速答案 將計畫與5 至 29 mL/min 嚴重腎功能範圍和中斷史相匹配。 為何這是正確的 memantine 仿單建議嚴重腎功能不全的目標劑量為 5 mg BID。它還指出，錯過數天可能需要從較低劑量重新開始並重新調整；單次錯過的劑量不應加倍。 簡單類比或心像 腎臟出口變窄會降低劑量上限，而長時間的暫停會使劑量調整回到起始坡道。 記憶點 CrCl 5 至 29：目標 5 mg BID；切勿加倍錯過的劑量。 NCLEX 決策規則 僅在檢查劑型、清除率、最後劑量和中斷持續時間後，才解釋目前的處方。 為何其他選項是錯誤的 正常的腎功能不需要嚴重腎功能上限，並且錯過一劑應按時恢復，而不是加倍。參考資料 1DailyMed: Memantine Hydrochloride Tablets嚴重腎功能不全的目標劑量和嚴重肝功能不全的注意事項 ## 臨床情境 memantine 劑量核對 確認劑型、Cockcroft-Gault 清除率、目前劑量、錯過天數、不良反應和授權的重新調整計畫。 ## 相同主題題目 - [A client is admitted to the emergency department after ingesting an unknown amount of acet…](https://mymerci.kr/pages/nclex_q.php?qn_id=362720&lang=zh-tw) - [A client with chronic heart failure is prescribed metoprolol 25 mg orally twice daily. Bef…](https://mymerci.kr/pages/nclex_q.php?qn_id=362756&lang=zh-tw) - [A 28-year-old client with type 1 diabetes receives regular insulin 6 units and NPH insulin…](https://mymerci.kr/pages/nclex_q.php?qn_id=362792&lang=zh-tw) - [A client receives IV vancomycin 1 g every 12 hours for MRSA bacteremia. Before the next do…](https://mymerci.kr/pages/nclex_q.php?qn_id=362833&lang=zh-tw) - [A client with bipolar disorder has been taking lithium carbonate 600 mg orally three times…](https://mymerci.kr/pages/nclex_q.php?qn_id=362894&lang=zh-tw) - [A nurse is monitoring a client receiving a continuous IV heparin infusion for pulmonary em…](https://mymerci.kr/pages/nclex_q.php?qn_id=363988&lang=zh-tw) - [A nurse is preparing to initiate a weight-based continuous IV unfractionated heparin infus…](https://mymerci.kr/pages/nclex_q.php?qn_id=364107&lang=zh-tw) - [A nurse is providing discharge teaching to a 65-year-old client newly prescribed warfarin …](https://mymerci.kr/pages/nclex_q.php?qn_id=364872&lang=zh-tw) ## 以其他語言閱讀 - [en](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=en) - [ko](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=ko) - [ja](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=ja) - [zh-TW](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=zh-tw) - [vi](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=vi) --- More free questions: [NCLEX-RN 題庫](https://mymerci.kr/pages/nclex_bank.php?lang=zh-tw) _僅供學習參考。實際臨床請遵循最新指引與所屬機構規範。_