# For each memantine finding, identify the appropriate interpretation.

> source: MyMerci (mymerci.kr)  
> url: https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=en  
> language: en  
> subject: Adverse Effects/Contraindications/Interactions  
> category: PPT

## Question

For each memantine finding, identify the appropriate interpretation.

|  | Dose clarification needed | Appropriate instruction | Does not trigger the severe-renal limit |
| --- | --- | --- | --- |
| CrCl 24 mL/min with immediate-release memantine 10 mg BID ordered |  |  |  |
| CrCl 24 mL/min with an authorized target of 5 mg BID |  |  |  |
| Client missed a single dose and plans to take the next scheduled dose without doubling |  |  |  |
| Client missed several days and plans to restart the full target dose without review |  |  |  |
| CrCl 68 mL/min with no hepatic impairment |  |  |  |

## Explanation

Severe renal impairment limits the target immediate-release dose to 5 mg BID. A 10-mg BID order needs clarification, and several missed days may require restarting lower and retitrating.

## In-depth explanation

Quick answer
Match the plan to the 5-to-29 mL/min severe-renal band and the interruption history.

Why this is correct
The memantine label recommends a target of 5 mg BID for severe renal impairment. It also states that several missed days may require resuming at a lower dose and retitrating; a single missed dose is not doubled.

Easy analogy or mental picture
A narrowed kidney exit lowers the dose ceiling, and a long pause sends titration back toward the starting ramp.

Memory hook
CrCl 5 to 29: target 5 mg BID; never double a missed dose.

NCLEX decision rule
Interpret the current prescription only after checking formulation, clearance, last dose, and interruption duration.

Why the other choices are wrong
Normal renal function does not require the severe-renal ceiling, and one missed dose is resumed on schedule rather than doubled.References
1DailyMed: Memantine Hydrochloride TabletsTarget dose for severe renal impairment and caution in severe hepatic impairment

## Clinical scenario

Memantine dose reconciliation
Verify formulation, Cockcroft-Gault clearance, current dose, days missed, adverse effects, and the authorized retitration plan.

## Related questions

- [A client is admitted to the emergency department after ingesting an unknown amount of acet…](https://mymerci.kr/pages/nclex_q.php?qn_id=362720&lang=en)
- [A client with chronic heart failure is prescribed metoprolol 25 mg orally twice daily. Bef…](https://mymerci.kr/pages/nclex_q.php?qn_id=362756&lang=en)
- [A 28-year-old client with type 1 diabetes receives regular insulin 6 units and NPH insulin…](https://mymerci.kr/pages/nclex_q.php?qn_id=362792&lang=en)
- [A client receives IV vancomycin 1 g every 12 hours for MRSA bacteremia. Before the next do…](https://mymerci.kr/pages/nclex_q.php?qn_id=362833&lang=en)
- [A client with bipolar disorder has been taking lithium carbonate 600 mg orally three times…](https://mymerci.kr/pages/nclex_q.php?qn_id=362894&lang=en)
- [A nurse is monitoring a client receiving a continuous IV heparin infusion for pulmonary em…](https://mymerci.kr/pages/nclex_q.php?qn_id=363988&lang=en)
- [A nurse is preparing to initiate a weight-based continuous IV unfractionated heparin infus…](https://mymerci.kr/pages/nclex_q.php?qn_id=364107&lang=en)
- [A nurse is providing discharge teaching to a 65-year-old client newly prescribed warfarin …](https://mymerci.kr/pages/nclex_q.php?qn_id=364872&lang=en)

## Read in another language

- [en](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=en)
- [ko](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=ko)
- [ja](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=ja)
- [zh-TW](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=zh-tw)
- [vi](https://mymerci.kr/pages/nclex_q.php?qn_id=514125&lang=vi)

---

More free questions: [NCLEX-RN Practice](https://mymerci.kr/pages/nclex_bank.php?lang=en)

_For study reference only. Always follow current clinical guidelines and your institution’s protocols._